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Nazia M. Alam, Cara M. Altimus, Robert M. Douglas, Samer Hattar, Glen T. Prusky; Photoreceptor Regulation of Spatial Visual Behavior. Invest. Ophthalmol. Vis. Sci. 2015;56(3):1842-1849. doi: 10.1167/iovs.14-15644.
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© ARVO (1962-2015); The Authors (2016-present)
To better understand how photoreceptors and their circuits support luminance-dependent spatial visual behavior.
Grating thresholds for optokinetic tracking were measured under defined luminance conditions in mice with genetic alterations of photoreceptor activity.
The luminance conditions that enable cone- and rod-mediated behavior, and the luminance range over which rod and cone functions overlap, were characterized. The AII amacrine pathway was found to support low-resolution and high-contrast function, with the rod–cone pathway supporting high-resolution and low-contrast function. Rods alone were also shown to be capable of driving cone-like spatial visual function, but only when cones were genetically maintained in a physiological dark state.
The study defined how luminance signals drive rod- and cone-mediated spatial visual behavior and revealed new and unexpected contributions for rods that depend on an interaction between cone and rod systems.
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