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Edoardo Abed, Marco Piccardi, Daniela Rizzo, Antonio Chiaretti, Lucia Ambrosio, Sergio Petroni, Rosa Parrilla, Anna Dickmann, Riccardo Riccardi, Benedetto Falsini; Functional Loss of the Inner Retina in Childhood Optic Gliomas Detected by Photopic Negative Response. Invest. Ophthalmol. Vis. Sci. 2015;56(4):2469-2474. doi: 10.1167/iovs.14-16235.
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© ARVO (1962-2015); The Authors (2016-present)
To determine whether the Ganzfeld ERG photopic negative response (PhNR), an assay of inner retinal activity, is altered in childhood optic glioma (OPG).
Seventeen pediatric patients with a diagnosis of OPG, established on neuro-ophthalmologic and brain/orbit magnetic resonance imaging (MRI) criteria, were enrolled. The examination protocol included determination of visual acuity (VA), fundus examination, retinal nerve fiber layer (RNFL) measurement with spectral-domain optical coherence tomography (SD-OCT) and photopic ERG. Fifteen normal children served as control group. Ten of the 17 OPG patients were retested 1 to 3 months after the first examination. Photopic ERGs were recorded after 10 minutes of light adaptation in response to a Ganzfeld flash presented on a steady light–adapting background. Amplitude and peak-time of b-wave and PhNR were measured.
Compared with normal values, PhNR amplitude was significantly reduced (P < 0.0001) in the OPG group. Peak-time of PhNR as well as b-wave amplitude and peak-time were similar in both patients and controls. Losses of PhNR were found in patients with involvement of either anterior or retro-chiasmatic optic pathways. Linear regression analysis showed significant positive correlation between RNFL thickness and PhNR amplitude (r2 = 0.34, P = 0.008). Mean percentage test–retest difference for PhNR amplitude and peak-time was 12% and 6%, respectively.
These findings indicate that flash ERG PhNR can detect a loss of inner retinal function in childhood OPGs supporting the use of this technique, as an adjunct to standard psychophysical and electrophysiological tests, to monitor visual function in OPG.
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