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Zhichao Wu, Chang J. Jung, Lauren N. Ayton, Chi D. Luu, Robyn H. Guymer; Test–Retest Repeatability of Microperimetry at the Border of Deep Scotomas. Invest. Ophthalmol. Vis. Sci. 2015;56(4):2606-2611. doi: https://doi.org/10.1167/iovs.14-15977.
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© ARVO (1962-2015); The Authors (2016-present)
The purpose of this study was to examine the test–retest repeatability of microperimetric sensitivity at the border of deep scotomas.
Thirty normal participants underwent two examinations, each on the Macular Integrity Assessment (MAIA) microperimeter and on the MP-1 microperimeter (four examinations in total). A customized stimulus pattern allowed microperimetric sensitivity to be measured at the border of the optic nerve head (ONH), which acted as a model for the border of a deep scotoma—and also at the macular and peripapillary region.
There were no significant changes in average point-wise sensitivity (PWS) values between the two examinations for all three regions using the MAIA microperimeter (P ≥ 0.262). The PWS coefficient of repeatability (CoR) was ±12.99 dB at the border of the ONH, which was significantly larger than points in the macular and peripapillary regions (P > 0.001). A significant decrease in average PWS, using the MP-1 microperimeter at the macular and peripapillary region (P < 0.001), meant that the PWS CoR could not be determined in these regions. No significant changes in average PWS were observed at the border of the ONH (P = 0.223), and the PWS CoR was ±7.52 dB in this region.
Microperimetric test–retest repeatability at the border of a deep scotoma was worse than at other areas of normal retina, and this highlights the limitation of applying a single estimate of test–retest repeatability to determine whether significant functional decline has occurred at the border of a deep scotoma.
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