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Tin A. Tun, Chen-Hsin Sun, Mani Baskaran, Michael J. A. Girard, John Mark S. de Leon, Ching-Yu Cheng, Hla M. Htoon, Tien Y. Wong, Tin Aung, Nicholas G. Strouthidis; Determinants of Optical Coherence Tomography–Derived Minimum Neuroretinal Rim Width in a Normal Chinese Population. Invest. Ophthalmol. Vis. Sci. 2015;56(5):3337-3344. doi: 10.1167/iovs.15-16786.
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© ARVO (1962-2015); The Authors (2016-present)
To characterize an optical coherence tomography (OCT)–derived parameter, Bruch's membrane opening–minimum rim width (BMO-MRW), and its association with demographic and clinical parameters in normal Chinese subjects.
Right eyes of 466 consecutive healthy subjects from a population-based study of Singaporean Chinese underwent Cirrus OCT imaging. The retinal internal limiting membrane (ILM) and BMO were automatically delineated using the built-in Cirrus algorithm. The standard 36 interpolated radial B-scans (72 BMO points, 5° increments) of each optic nerve head were manually extracted from the central circle (3.46-mm diameter). We used Matlab to measure the shortest distance from the BMO points to the ILM. Associations of BMO-MRW with demographic and clinical parameters were evaluated using marginal general estimating equations analysis.
There was a slight preponderance of male subjects (50.9%), with a mean age of 54.8 ± 7.63 years. Mean BMO-MRW was 304.67 ± 58.96 μm (range, 173.32–529.23 μm), which was highly associated with OCT-derived disc area (DA) (β = −91.78, P < 0.001) and rim area (RA) (β = 194.31, P < 0.001), followed by spherical refractive error (SRE) (β = −2.23, P = 0.02) and retinal nerve fiber layer (RNFL) thickness (β = 0.5, P = 0.04), after adjusting for the associated factors such as age, sex, intraocular pressure (IOP), and vertical cup–disc ratio (VCDR).
Disc area and RA had the strongest association with BMO-MRW, followed by SRE and RNFL thickness. The availability of this normative database will facilitate optic nerve head assessment using the BMO-MRW parameter in Chinese subjects.
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