June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Lamina cribrosa pore characteristics in eyes with primary open-angle glaucoma: A swept-source optical coherence tomography study
Author Affiliations & Notes
  • Yong Woo Kim
    Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea (the Republic of)
  • Byeong Wook Yoo
    Interdisciplinary Program, Bioengineering Major, Graduate School, Seoul National University, Seoul, Korea (the Republic of)
  • Jin Wook Jeoung
    Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea (the Republic of)
  • Hee Chan Kim
    Department of Biomedical Engineering, College of Medicine and Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul, Korea (the Republic of)
  • Ki Ho Park
    Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea (the Republic of)
  • Footnotes
    Commercial Relationships Yong Woo Kim, None; Byeong Wook Yoo, None; Jin Wook Jeoung, None; Hee Chan Kim, None; Ki Ho Park, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 1003. doi:
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      Yong Woo Kim, Byeong Wook Yoo, Jin Wook Jeoung, Hee Chan Kim, Ki Ho Park; Lamina cribrosa pore characteristics in eyes with primary open-angle glaucoma: A swept-source optical coherence tomography study. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1003.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To evaluate the characteristics of lamina cribrosa (LC) pores in eyes with primary open-angle glaucoma (POAG) using swept-source optical coherence tomography (SS-OCT).

 
Methods
 

Patients with POAG (n=30 eyes) and age-matched healthy individuals (n=10 eyes) were recruited. Optic disc scans were performed by SS-OCT, and 3 mm×3 mm×2.6 mm (512×256×963 pixel) data cube were acquired. Each data volume was reconstructed as C-scan slices by built-in en-face viewer (EnView, DRI OCT-1, Topcon Medical Systems, Oakland, NJ). For each C-scan slices, the automated segmentation procedure, including local contrast enhancement and local thresholding, were performed by Matlab R2014a (The MathWorks, Inc., Natick, MA). LC parameters including pore count, pore diameter, standard deviation (SD) of pore diameter, pore ovality, pore area, pore volume and beam thickness were automatically measured in four quadrants (superior, inferior, nasal and temporal) and compared between the groups. LC parameters associated with increased mean deviation (MD) of visual field (VF) were investigated using general linear model.

 
Results
 

The average MD of VF for the POAG and healthy eyes was -9.30±6.10 dB and 1.21±0.65 dB, respectively. There was no significant difference in pore count, pore diameter, SD of pore diameter, and pore volume between the two groups (P>0.05). The pore area was significantly lower in temporal area (641.8±185.8 μm2, P=0.01) and marginally larger in superior area (862.3±206.5 μm2, P=0.052) in POAG eyes compared to healthy eyes (703.3±248.0 and 821.7±166.3 μm2, respectively). The pore ovality was significantly larger at all quadrants in POAG eyes (mean, 1.71±0.16) than in healthy eyes (mean, 1.55±0.19, P=0.009). The beam thickness tended to be lower in POAG eyes, while only superior quadrant showed statistical significance (POAG, 416.3±39.5 μm vs. Healthy, 449.1±55.2 μm, P=0.047). In the multivariate analysis, the pore ovality was significantly associated with decreased MD of VF (beta=-15.161, P=0.006).

 
Conclusions
 

Quantitative evaluation of LC pores using SS-OCT demonstrated regional pore area variability and increased pore ovality in POAG eyes. The pore ovality revealed linear relationship with glaucoma severity. Assessment of LC pores may provide structure-function related information in glaucoma patients.  

 
Structure-Function Relationship Between LC pore ovality and VF MD
 
Structure-Function Relationship Between LC pore ovality and VF MD

 
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