June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Vertical asymmetry of lamina criborosa tilt angles from Bruch’s membrane opening plane
Author Affiliations & Notes
  • Takuhei Shoji
    Ophthalmology, Saitama Medical University, Iruma, Japan
  • Hiroto Kuroda
    Ophthalmology, Saitama Medical University, Iruma, Japan
  • Masayuki Suzuki
    Ophthalmology, Saitama Medical University, Iruma, Japan
  • Makoto Araie
    Ophthalmology, Saitama Medical University, Iruma, Japan
    Kanto Central Hospital, Tokyo, Japan
  • Masanori Hangai
    Ophthalmology, Saitama Medical University, Iruma, Japan
  • Shin Yoneya
    Ophthalmology, Saitama Medical University, Iruma, Japan
  • Footnotes
    Commercial Relationships Takuhei Shoji, None; Hiroto Kuroda, None; Masayuki Suzuki, None; Makoto Araie, None; Masanori Hangai, None; Shin Yoneya, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 1006. doi:
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      Takuhei Shoji, Hiroto Kuroda, Masayuki Suzuki, Makoto Araie, Masanori Hangai, Shin Yoneya; Vertical asymmetry of lamina criborosa tilt angles from Bruch’s membrane opening plane. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1006.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: Growing evidence points to morphological features of lamina cribrosa and optic disc being important pathogenesis of glaucoma and myopic neuropathy. We performed a cross sectional clinical study to evaluate the vertical asymmetry of the lamina cribrosa (LC) tilt angles (LCTA) from the Bruch’s membrane opening (BMO) and investigate related factors.

Methods: Thirty glaucomatous (17 patients) and 29 non-glaucomatous (16 subjects) eyes were enrolled. Optic nerve head B-scans were obtained using optical coherence tomography (OCT) with a wide bandwidth femtosecond Mode-locked Laser. Lines were drawn from the superior temporal (ST) to inferior nasal (IN) and from the inferior temporal (IT) to superior nasal (SN) directions (±45-degree rotated with horizontal line), and the angle between the BMO plane inner edge and approximate best-fitting line for the anterior LC plane was measured as LCTA.<br />

Results: The median (interquartile range, [IQR]) ST to IN LCTA (ST-LCTA) and IT to SN LCTA (IT-LCTA) were 3.0 (1.8-4.7) and 9.2 (6.6-6.4) degrees, respectively, in non-glaucomatous eyes, and 3.3 (2.5-6.4) and 11.0 (5.3-18.6) degrees, respectively, in the glaucomatous eyes. IT-LCTA was significantly greater than ST-LCTA (p < 0.001) and correlated with refractive errors after adjustment for other factors in both normal and glaucomatous eyes. (p < 0.001).

Conclusions: The differences show the vertical asymmetry of LC tilting from BMO plane, and these novel parameters have important implications for investigation of the correlation between myopia, glaucoma, and morphological lamina features.

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