June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Contrast Sensitivity by M&S Smart System II and Visual field Parameters in Patients with Primary Open-Angle Glaucoma
Author Affiliations & Notes
  • Jessica L Liu
    Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL
    Saint Louis University School of Medicine, St. Louis, MO
  • Sachin Jain
    Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL
  • Tieu Vy Nguyen
    Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL
  • J Jason McAnany
    Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL
  • Jacob T Wilensky
    Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL
  • Ahmad A Aref
    Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL
  • David Hillman
    Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL
  • Thasarat S Vajaranant
    Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL
  • Footnotes
    Commercial Relationships Jessica Liu, None; Sachin Jain, None; Tieu Vy Nguyen, None; J Jason McAnany, None; Jacob Wilensky, None; Ahmad Aref, None; David Hillman, None; Thasarat Vajaranant, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 1048. doi:
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    • Get Citation

      Jessica L Liu, Sachin Jain, Tieu Vy Nguyen, J Jason McAnany, Jacob T Wilensky, Ahmad A Aref, David Hillman, Thasarat S Vajaranant; Contrast Sensitivity by M&S Smart System II and Visual field Parameters in Patients with Primary Open-Angle Glaucoma. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1048.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

Loss of contrast sensitivity (CS) may occur early in glaucoma, and precede clinically detectable changes in visual acuity (VA) and visual field (VF). CS testing by a computerized vision-testing device (M&S Smart System II) has been validated against thea gold standard Pelli-Robson CS testing. We determined relationships between CS by the M&S Smart System II and routine visual functional measures in patients with glaucoma.

 
Methods
 

We recruited patients with primary open-angle glaucoma (POAG) without other eye conditions. Each patient underwent 1) VA and CS testing in a standardized manner using a calibrated M&S Smart System II; and 2) VF testing (Humphrey SITA 24-2). Inclusion criteria included VA > 20/40 and reliable VF testing (fixation losses, false positives and false negatives < 33%). Spearman rank correlations were used to determine relationships within CS, VA, and VF parameters including mean deviation (MD), pattern standard deviation (PSD), and visual field index (VFI). Only the better eye was recruited for analysis based on MD. Based on the Bonferroni correction for multiple comparisons, correlations were considered statistically significant if p-value < 0.005 (two-tailed).

 
Results
 

A total of 108 eyes of 108 patients met the inclusion criteria and were included for analysis. The mean age of the patients included was 65.81±12.74 years old. The mean BCVA was 20/25 (logMAR: 0.09±0.10) and the mean CS was 1.37±0.16. The spearman rank correlation coefficients are shown in Table 1. Amongst the VF parameters, VA correlated most strongly with MD. CS correlated most strongly with MD and VFI.<br /> TABLE 1: Correlations between Contrast Sensitivity Testing and Visual Functional Measures

 
Conclusions
 

When compared to VA, CS correlates to a greater degree with all three VF parameters. Our results suggest that CS can serve as a surrogate for VF measures, supporting routine use of CS testing. Given that CS testing by the M&S System can be done quickly, incorporation into a budy clinical practice is practical. Patients with POAG often experience decreased vision without discernable changes in their VA. Since VF testing is not routinely performed at each visit, CS testing could be used more frequently to monitor subjective deterioration in quality of vision in patients with POAG. The strong correlations between CS, MD and VFI drive home these conclusions.  

 
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