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Hiroshi Sasaki, Eri Shibuya, Mai Takahashi, Ayako Okamoto, Norihiro Mita, Natsuko Hatsusaka, Shinsuke Shibata, Teppei Shibata, Kazuyuki Sasaki, Eri Kubo; Effect of forward light scattering on visual function in eyes with cortical cataract. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1070.
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© ARVO (1962-2015); The Authors (2016-present)
We examined correlations between forward light scattering (FLS) and visual function in cortical cataract (COR) and transparent (TP) eyes.
Of subjects in 2013 Monzen Eye Study and Kanazawa Medical University Hospital cataract surgery patients from July 2013 to March 2014, 39 COR eyes of 35 subjects (66.5±6.0 yrs) were compared with 42 TP eyes of 42 subjects (57.2±8.7 yrs) as control. Cases with ocular disease except for refractive error were excluded. COR was examined under maximal mydriasis by the same examiner, graded in 4 stages (Grade 0 to 3) according to WHO classification system, and categorized CEN+/- by opacity within/outside the central 3 mm diameter of the pupil. Opacity within this 3 mm diameter area was measured with transillumination imaging by anterior eye segment analysis system EAS-1000 (NIDEK). FLS was measured by C-Quant (OCULUS®) and stray light correction level (Log(s)) was calculated. Total higher-order aberration (HOA) in the 4 mm pupil diameter, retinal image contrast (RIC) in the 3 mm entrance pupil, and 25% day and evening vision contrast visual acuity (CVA) were measured by KR-9000PW (TOPCON), PSF-1000 (TOPCON), and CAT-2000 (NEITZ), respectively.
FLS was higher in COR (1.38±0.25) than in TP (1.13±0.22) (p<0.001). There was no significant correlation between FLS and age in COR or TP. FLS in COR increased with grade. CEN+ (1.45±0.20) had higher FLS than CEN- (1.26±0.30) (p<0.05) with CEN+ grade 1 (1.36±0.25), 2 (1.43±0.13), and 3 (1.51±0.24). There was a positive correlation between area of opacity of CEN+ and FLS (p<0.05). CEN- with COR grade 2 (1.37±0.32) had higher FLS than TP (p<0.05). In TP eyes, FLS was significantly correlated with decreased best corrected visual acuity (p<0.01), increased total ocular HOA (p<0.01) and total intraocular HOA (p<0.05), but not in COR eyes. There was no correlation between FLS and CVA in TP or COR, however, RIC in COR showed a negative correlation with FLS in low and intermediate frequency domains (p<0.05).
FLS in TP at age 40s-60s was little affected by aging. In COR, FLS increased with severity of opacity and opacity in the pupillary area, decreasing RIC. It was suggested that higher FLS is a major factor in decreased visual function.
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