June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Quantification of corneal biomechanical properties by optical coherence elastography and a Lamb wave model
Author Affiliations & Notes
  • Zhaolong Han
    Department of Biomedical Engineering, University of Houston, Houston, TX
  • Salavat R. Aglyamov
    Department of Biomedical Engineering, University of Texas at Austin, Austin, TX
  • Jiasong Li
    Department of Biomedical Engineering, University of Houston, Houston, TX
  • Manmohan Singh
    Department of Biomedical Engineering, University of Houston, Houston, TX
  • Shang Wang
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX
  • Srilatha Vantipalli
    College of Optometry, University of Houston, Houston, Houston, TX
  • Chen Wu
    Department of Biomedical Engineering, University of Houston, Houston, TX
  • Chih-hao Liu
    Department of Biomedical Engineering, University of Houston, Houston, TX
  • Michael D Twa
    School of Optometry, University of Alabama, Birmingham, AL
  • Kirill Larin
    Department of Biomedical Engineering, University of Houston, Houston, TX
  • Footnotes
    Commercial Relationships Zhaolong Han, None; Salavat R. Aglyamov, None; Jiasong Li, None; Manmohan Singh, None; Shang Wang, None; Srilatha Vantipalli, None; Chen Wu, None; Chih-hao Liu, None; Michael Twa, None; Kirill Larin, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 1105. doi:
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      Zhaolong Han, Salavat R. Aglyamov, Jiasong Li, Manmohan Singh, Shang Wang, Srilatha Vantipalli, Chen Wu, Chih-hao Liu, Michael D Twa, Kirill Larin; Quantification of corneal biomechanical properties by optical coherence elastography and a Lamb wave model. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1105.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To quantitatively assesse the corneal viscoelasticity by using optical coherence elastography (OCE) and a Lamb wave model.

 
Methods
 

Air-pulse OCE experiments were conducted on porcine corneas to obtain the elastic displacement distributions which behaved as an elastic wave. Phase velocities of the air-pulse induced elastic waves were extracted by spectral analysis and used for calculating the Young’s moduli of the samples using the Rayleigh-Lamb frequency equation (RLFE). For cornea, the RLFE was modified to consider the effect of the aqueous humor. Experiments were performed on 2% agar phantoms (n=3) and then applied to porcine corneas (n=3) in situ.

 
Results
 

Validation experiments were performed on 2% agar phantoms (Figure a) and compared with uniaxial compressional tests (Figure b), which demonstrated the accuracy and feasibility of the RLFE method to reconstruct sample’s mechanical properties. Figure c demonstrates results from RLFE application to process OCE data from porcine corneas: the Young’s moduli were estimated to be ~60 kPa with a shear viscosity ~0.33 Pa∙s.

 
Conclusions
 

OCE combining RLFE is a promising method for noninvasive quantification of the corneal biomechanical properties and may potentially be useful for clinical ophthalmological applications.  

 
Validation experiments were performed on 2% agar phantoms (Figure a) and compared with uniaxial compressional tests (Figure b). Figure c demonstrates results for porcine corneas: the Young’s moduli were estimated to be ~60 kPa with a shear viscosity ~0.33 Pa∙s.
 
Validation experiments were performed on 2% agar phantoms (Figure a) and compared with uniaxial compressional tests (Figure b). Figure c demonstrates results for porcine corneas: the Young’s moduli were estimated to be ~60 kPa with a shear viscosity ~0.33 Pa∙s.

 
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