June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Visual function and corneal endothelium analysis in patients with well-suppressed HIV infection: a matched case-control study
Author Affiliations & Notes
  • Nazli Demirkaya
    Ophthalmology, Academic Med Ctr Amsterdam, Amsterdam, Netherlands
  • Ferdinand Wit
    Infectious Diseases, Academic Medical Center, Amsterdam, Netherlands
    Amsterdam Institute for Global Health and Development, Amsterdam, Netherlands
  • Thomas J T P Van Den Berg
    Netherlands Ophthalmic Research Institute, Amsterdam, Netherlands
  • Peter Reiss
    Infectious Diseases, Academic Medical Center, Amsterdam, Netherlands
    Amsterdam Institute for Global Health and Development, Amsterdam, Netherlands
  • Frank D Verbraak
    Ophthalmology, Academic Med Ctr Amsterdam, Amsterdam, Netherlands
  • Footnotes
    Commercial Relationships Nazli Demirkaya, None; Ferdinand Wit, None; Thomas Van Den Berg, None; Peter Reiss, Bristol Myers Squibb (F), Merck (F), Institution from Gilead Sciences (F), Janssen Pharmaceuticals (F), ViiV (F); Frank Verbraak, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 1147. doi:
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      Nazli Demirkaya, Ferdinand Wit, Thomas J T P Van Den Berg, Peter Reiss, Frank D Verbraak, AgehIV Neuro Sub-Studygroup Amsterdam; Visual function and corneal endothelium analysis in patients with well-suppressed HIV infection: a matched case-control study. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1147.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To assess visual function and features of the corneal endothelium in HIV-infected adults by psychophysical tests and corneal specular microscopy.

Methods: Fifty-four HIV-infected men and 43 HIV-negative control subjects were enrolled from the prospective AGEhIV cohort study on age-associated non-communicable co-morbidity in Amsterdam. All participants underwent a standard ophthalmic examination. Visual function was assessed by Pelli Robson and Mars contrast sensitivity charts, C-Quant straylight meter, Lanthony Desaturated Panel D-15, Rarebit Fovea Test and Frequency Doubling Perimetry. The Topcon specular microscope SP-1P was used to assess features of the corneal endothelium in a subset of the study participants (25 HIV-infected patients and 12 HIV-negative controls). Only right eyes were included for analysis by multivariable regression models.

Results: Correcting for age, we did not detect significant differences in visual function between HIV-infected individuals and controls, with the only exception of a slightly higher straylight value in the patient group. Corneal endothelium parameters were also similar between the two groups.<br /> In the patients, we observed significant associations between a longer duration of HIV-infection and features of the corneal endothelium consistent with aging (lower endothelial cell density, higher variation in cell size and an increased average cell size). Patients with a prior diagnosis of AIDS had a significant larger average cell size than patients who never had developed AIDS.

Conclusions: Visual function and corneal endothelium parameters are not significantly different between patients with well-suppressed HIV-infection and healthy controls, although a longer duration of HIV is associated with changes in the corneal endothelium consistent with aging.

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