June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Acute corneal toxicity of Xalatan and some generics
Author Affiliations & Notes
  • Daisuke Inoue
    Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki City, Japan
  • Masafumi Uematsu
    Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki City, Japan
  • Yasser Helmy Mohamed
    Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki City, Japan
  • Naoko Onizuka
    Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki City, Japan
  • Ryotaro Ueki
    Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki City, Japan
  • Azusa Fujikawa
    Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki City, Japan
  • Hitoshi Sasaki
    Department of Hospital Pharmacy, Nagasaki University Hospital of Medicine and Dentistry, Nagasaki City, Japan
  • Takashi Kitaoka
    Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki City, Japan
  • Footnotes
    Commercial Relationships Daisuke Inoue, None; Masafumi Uematsu, None; Yasser Mohamed, None; Naoko Onizuka, None; Ryotaro Ueki, None; Azusa Fujikawa, None; Hitoshi Sasaki, None; Takashi Kitaoka, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 1187. doi:
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    • Get Citation

      Daisuke Inoue, Masafumi Uematsu, Yasser Helmy Mohamed, Naoko Onizuka, Ryotaro Ueki, Azusa Fujikawa, Hitoshi Sasaki, Takashi Kitaoka; Acute corneal toxicity of Xalatan and some generics. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1187.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To investigate the corneal toxicity of Xalatan and three latanoprost generics using transepithelial electrical resistance (TER) and scanning electron microscopy (SEM).

Methods: Corneal TER changes after a 60-second exposure to Xalatan (latanoprost 0.005% preserved with 0.02% BAC), and latanoprost generics (Latanoprost PF BAC free, Latanoprost Nitten SB containing sodium benzoate, and Latanoprost Towa containing 0.01% BAC with sodium chloride polysorbate80 as additive) were measured in living rabbits. Corneal damage was also examined by SEM. Hank’s balanced salt solution was used as a control.

Results: There was a significant decrease in the corneal TER after exposure of the cornea to Xalatan and all latanoprost generics. All latanoprost generics showed less TER decrease in the corneal TER as compared to Xalatan. SEM revealed that superficial cells of Xalatan-treated corneas were damaged and exhibited degenerated microvilli. Conversely, the superficial cells of corneas exposed to HBSS or all latanoprost generics appeared normal and had normal microvilli under SEM examinations.

Conclusions: The corneal toxicity of Xalatan is greater than that of latanoprost generics. Xalatan contains 0.02% BAC, which may be responsible for the corneal toxicity.

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