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Jacques Bouche-Pillon, Philippe Koehrer, Alain M Bron, Catherine P Garcher, Christine Binquet, Christophe tzourio, Lionel Bretillon, Niyazi Acar; Analysis of the vitreomacular interface in a French population-based study (The MONTRACHET study: Maculopathy, Optic Nerve, nuTRition, neurovAsCular and HEarT diseases). Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1198.
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The aim of this study was to investigate the prevalence and distribution of vitreomacular adhesion (VMA) in a French population aged over 75 years and enrolled in the MONTRACHET study.
An earlier three-city study (3C; 1999) recruited and studied 9294 subjects aged 65 years or more drawn from three French cities (Bordeaux, Dijon and Montpellier). After a 10-year follow up, Dijon’s cohort had a complete ophthalmic examination as part of the MONTRACHET study. Vitreomacular interface (VMI) was analysed with a spectral-domain OCT. Vitreomacular adhesion (VMA) in each patient was classified according to the IVTS (International Vitreomacular Traction Study) criteria, defining the presence VMA, vitreomacular traction (VMT) isolated or associated with a foveal distorsion.
One thousand one hundred and fifty three subjects were included in the study; the median age was 81 [76-96] years. Prevalence of vitreomacular adhesion was 12.2%. VMA affected both eyes in 28.5% of cases (80 patients). The median size of the diameter of vitreous attachment to the macular surface was 1377 [50-5639] µm. Attachment was focal (≤1500 ųm) for 52.3% of cases (147 eyes) and broad (>1500 ųm) for 47.7% of cases (134 eyes). Prevalence of isolated VMT was 0.9% (22 eyes) and was focal (<1500 µm) in all cases. Prevalence of lamellar holes was 0.6% (13 eyes) and macular pseudoholes was 0.2% (4 eyes). Prevalence of full-thickness macular hole was 0.01% (2 eyes). ARMD (Age Related Macular Degeneration) was associated with VMA in 4 eyes (2.5 %).
The analysis of VMI is interesting due to the emergence of enzymatic vitreolysis. These results provide new population data from French subjects aged 75 years and above.<br /> <br /> These results from the MONTRACHET study are the first to analyse and classify VMA using the new classification system of the International Vitreomacular Traction Study Group in a population based study.
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