June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Critical Appraisal of Clinical Practice Guidelines for Age-Related Macular Degeneration
Author Affiliations & Notes
  • Annie Wu
    Warren Alpert Medical School of Brown University, Providence, RI
    Section of Ophthalmology, Providence VA Medical Center, Providence, RI
  • Connie Wu
    Warren Alpert Medical School of Brown University, Providence, RI
    Section of Ophthalmology, Providence VA Medical Center, Providence, RI
  • Benjamin Young
    Warren Alpert Medical School of Brown University, Providence, RI
    Section of Ophthalmology, Providence VA Medical Center, Providence, RI
  • Dominic J Wu
    Warren Alpert Medical School of Brown University, Providence, RI
    Section of Ophthalmology, Providence VA Medical Center, Providence, RI
  • Curtis Margo
    Ophthalmology, Morsani College of Medicine, Tampa, FL
  • Paul B Greenberg
    Warren Alpert Medical School of Brown University, Providence, RI
    Section of Ophthalmology, Providence VA Medical Center, Providence, RI
  • Footnotes
    Commercial Relationships Annie Wu, None; Connie Wu, None; Benjamin Young, None; Dominic Wu, None; Curtis Margo, None; Paul Greenberg, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 141. doi:
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    • Get Citation

      Annie Wu, Connie Wu, Benjamin Young, Dominic J Wu, Curtis Margo, Paul B Greenberg; Critical Appraisal of Clinical Practice Guidelines for Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):141.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To evaluate the methodological quality of age-related macular degeneration (AMD) clinical practice guidelines (CPGs).

Methods: AMD CPGs published by the American Academy of Ophthalmology (AAO) and Royal College of Ophthalmologists (RCO) were appraised by independent reviewers using the Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument, which comprises six domains (Scope and Purpose, Stakeholder Involvement, Rigor of Development, Clarity of Presentation, Applicability, and Editorial Independence) and an Overall Assessment score summarizing methodological quality across all domains.

Results: Average domain scores ranged from 35% to 83% for the AAO CPG and 17% to 83% for the RCO CPG. Intraclass correlation coefficients for the reliability of mean scores for the AAO and RCO CPGs were 0.74 and 0.88, respectively. The strongest domains were Scope and Purpose and Clarity of Presentation. The weakest were Stakeholder Involvement (AAO) and Editorial Independence (RCO).

Conclusions: Future AMD CPGs can be improved by involving all relevant stakeholders in guideline development, ensuring transparency of guideline development and review methodology, improving guideline applicability with respect to economic considerations, and addressing potential conflicts of interest within the development group.

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