June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Retinopathy screening by flicker electroretinogram in diabetic patients. (subtitle: Diabetic retinopathy screening by ERG. )
Author Affiliations & Notes
  • Motonobu Fukuo
    Diabetes Ophthalmology, Tokyo Women's Medical Unv, Shinjuku-ku, Japan
  • Akira Hirose
    Diabetes Ophthalmology, Tokyo Women's Medical Unv, Shinjuku-ku, Japan
  • Shigehiko Kitano
    Diabetes Ophthalmology, Tokyo Women's Medical Unv, Shinjuku-ku, Japan
  • Mineo Kondo
    Ophthalmology, Mie Univ Graduate school of Medicine, Tsu, Japan
  • Footnotes
    Commercial Relationships Motonobu Fukuo, None; Akira Hirose, None; Shigehiko Kitano, None; Mineo Kondo, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 1434. doi:
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      Motonobu Fukuo, Akira Hirose, Shigehiko Kitano, Mineo Kondo; Retinopathy screening by flicker electroretinogram in diabetic patients. (subtitle: Diabetic retinopathy screening by ERG. ). Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1434.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: Retinopathy screening is important in diabetic patients. RETeval™ can easily evaluate the implicit time of flicker electroretinogram (ERG) of eyes using not contact-lens but skin electrodes, with no dark adaptation nor mydriasis, resulting to reduce the burden and invasion on patients in examination compared to the traditional ERG methods. We studied the capacity of RETeval in screening on retinopathy of diabetic patients.

Methods: The Tokyo Women’s Medical University’s Ethics Committee approved this study. A hundred and eighty eyes of 90 diabetic patients who visited our department for the first time with written informed consent were included. Before mydriasis, the implicit time of flicker ERG was recorded for each eye using RETeval with white stimulus light, 8 Td-s stimulus intensity and 28.3 Hz frequency. Retinopathy was examined with ophthalmoscopy and fudus photograph after mydriasis and was defined as positive (DR(+)) by the presence of any retinopathy, otherwise as negative (DR(-)). The relation between retinopathy and implicit time was evaluated by the Wilcoxon rank-sum test and the receiver-operator characteristic (ROC) analysis. P<0.05 was considered significant.

Results: The mean age of 90 patients (57 males, 33 females) was 56.2 (SD ± 13.2, range: 23-83) years. Of the 180 eyes, 118 eyes were DR(-) and 62 eyes were DR(+). Implicit time showed a significant difference (P<0.001) between the DR(-) and the DR(+) eye groups (mean±SD: 34.4±1.8ms and 37.4±2.5ms respectively). AUC (area under the curve) in ROC curve analysis was 0.860. At cut-off values of 35.0 and 34.5ms for implicit time, sensitivities were 87% and 97%, specificities were 64% and 54% for DR(+) respectively.

Conclusions: RETeval seemed useful in screening retinopathy in diabetics especially for its ability to rule out the DR(-) eyes in our cohort.

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