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Beatriz Jatziri Perez-Aragon, David De La O-Altamirano, Alberto Gil-Gutiérrez, Abel Ramirez-Estudillo, Araceli Rojas, Atzin Robles-Contreras; Antiinflammatory effect of silicone oil in patients treated for Diabetic Retinal Detachment Tractional. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):153.
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© ARVO (1962-2015); The Authors (2016-present)
There is controversy about the inflammatory effect (pro or anti) of silicone oil as tamponade. So the purpose of this study was to determine, whether the presence of intravitreal silicone as a treatment in patients with diabetic tractional retinal detachment modify the levels of inflammatory cytokines
A prospective, transversal, observational and analytical study was conducted. Samples were taken during the removal of intravitreal silicone patients who were previously treated with silicone oil as tamponade, also the vitreous of patients undergoing vitrectomy for diabetic tractional retinal detachment was obtained. Silicone oil and vitreous cytokines were measured by CBA (Human Inflammatory Cytokine Kit, BD Bioscience; IL8, IL1β, IL6, IL10, TNF, IL12p). The detection limit was determined interleukins under standardization curve provider. Samples were analyzed using Kolmogorov- Smirnoff test to determine the type of distribution, t test for group comparisons (Silicone oil vs vitreous) were applied, where a value of p < 0.05 was considered statistically significant.
A total of 12 samples of silicon and 16 vitreous. Proinflammatory cytokines were detected in silicon at significantly lower levels than in vitreous IL8, 5.27 ± 9.09pg/ml against 74.7 ± 101.5pg/ml (p=0.007); IL6, 13.95 ± 33.44pg/ml against 58.08 ± 67.62pg/mL (p=0.037). Silicone concentration in antiinflammatory factors such as IL10 was higher than in the vitreous analyzed 0.78 ± 0.49pg/ml vs 0.34±0.43 pg/ml; p=0.034.
Intravitreal silicone acts trapping surrounding inflammatory cytokines and their concentration could be related to an antiinflammatory effect by decreasing the presence of fibrosis and retinal regrowth.
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