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Shima Shah, Simon Sheung Man Fung, Julia Elizabeth Theodossiades, Yusrah Shweikh, Olivia Li, Su-yin Koay, Khilan Shah, Mark R Wilkins, Romesh Angunawela; Outcomes of pre-cut DSAEK for endothelial failure at Moorfields Eye Hospital 2013-2014. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1566.
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Since June 2013, The Moorfields Lions Eye Bank has supplied pre-cut donor material for Descemet Stripping Automated Endothelial Keratoplasty (DSAEK). This study reviews the clinical outcomes of patients who have undergone DSAEK with pre-cut tissue at Moorfields Eye Hospital (MEH), London.
All patients who underwent pre-cut DSAEKs from June 2013 were included in this study. Clinical records were retrospectively reviewed and data was collected on surgical indication, graft detachment and survival.
Data was collected for 32 eyes of 27 patients, with a mean age of 72 years. Twenty seven eyes had no comorbidity, three had advanced glaucoma and two were amblyopic. Two eyes had undergone previous glaucoma surgery.<br /> <br /> Surgical indications were: Fuchs’ endothelial dystrophy (24), pseudophakic bullous keratopathy (2), decompensated cornea (2), failed DMEK (2) and failed PK (2). Surgery was performed by nineteen surgeons; comprising four consultants and fifteen fellows. Five (16%) grafts detached within a week and were successfully repositioned. Three partial detachments spontaneously resolved. One DSAEK showed signs of primary graft failure at the three month post-operative stage. No graft rejection episodes were reported.
Pre-cut DSAEK outcomes in a teaching hospital environment are comparable to published series. Further standardisation in DSAEK surgical techniques could enhance consistency of clinical outcomes
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