June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Evaluation the Change of Corneal Epithelium Thickness after Pterygium Excision with Conjunctival Autograft Transplantation by Fourier Domain Optical Coherence Tomography(FD-OCT).
Author Affiliations & Notes
  • Dan Wu
    Ophthalmology, Shanghai Eye & ENT Hospital of Fudan University, Shanghai, China
  • jianjiang xu
    Ophthalmology, Shanghai Eye & ENT Hospital of Fudan University, Shanghai, China
  • Footnotes
    Commercial Relationships Dan Wu, None; jianjiang xu, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 1604. doi:
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      Dan Wu, jianjiang xu, ; Evaluation the Change of Corneal Epithelium Thickness after Pterygium Excision with Conjunctival Autograft Transplantation by Fourier Domain Optical Coherence Tomography(FD-OCT).. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1604.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To evaluate the change of corneal epithelial thickness after pterygium excision surgery by FD-OCT.

 
Methods
 

Twenty-two patients (24 eyes) with the diagnosis of primary pterygium were enrolled. They underwent pterygium excision combined with conjunctival autograft transplantation. Twenty-five volunteers (25 eyes) served as the normal control group. FD-OCT was performed preoperatively and 1, 2, 3, 5, 7 days postoperatively to measure the thickness of corneal epithelium at 1mm and 2mm anterior to the nasal or temporal scleral spur. Corneal fluorescein staining was performed simultaneously. Comparisons on the thickness of corneal epithelium were made between preoperative values and postoperative ones.

 
Results
 

The thickness of cornea epithelium at 1mm anterior to the scleral spur was 43.81±2.55μm in normal subjects. At day 1 after surgery, corneal epithelial thickness at the same location was (21.28±5.72)μm and then increased to (39.94±5.47)μm at day 7 postoperatively. All the difference on postoperative days had statistically significant (Figure 1,t=-17.69,-14.97,-10.63,-9.86,-3.15, p<0.05). The thickness of cornea epithelium at 2mm anterior to the scleral spur was (40.50±3.17)μm in normal subjects. At day 1 after surgery, corneal epithelial thickness at the same location was (24.02±5.92)μm and then increased to (40.34±5.69)μm at day 7 postoperatively. All the difference on postoperative days except day 7 had statistically significant (t=-12.08,-10.27,-6.18,-2.99, p<0.05). Cornea epithelium at this location repaired sooner than that at 1mm anterior to the scleral spur. At day 1 after surgery, corneal epithelium defect area were (39.31±22.77) mm2 and then decreased to (1.01±1.72) mm2 at 7 days (Figure 2,P<0.05). At day 7 postoperative, 66.7% patients had a corneal epithelium complete recovery with no fluorescein staining.

 
Conclusions
 

FD-OCT was the effective instrument for observing the change of limbus-peripheral cornea epithelium thickness. Within 7 days postoperatively, cornea epithelium restored almost normal. After pterygium surgery, limbus-peripheral cornea epithelium restored from the central to peripheral cornea.  

 
The thickness of corneal epithelial at 1mm and 2mm anterior to the temporal or nasal scleral spur measured by FD-OCT.
 
The thickness of corneal epithelial at 1mm and 2mm anterior to the temporal or nasal scleral spur measured by FD-OCT.
 
 
Corneal fluorescein staining on 1, 2, 3, 5, 7 days postoperatively.
 
Corneal fluorescein staining on 1, 2, 3, 5, 7 days postoperatively.

 
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