June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Evaluating the Utility of Speckle-Variance Optical Coherence Tomography for Assessing the Human Macula
Author Affiliations & Notes
  • Zaid Mammo
    Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada
  • Chandra Bala
    Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada
    Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, WA, Australia
  • Jing Xu
    School of Engineering Science, Simon Fraser University, Burnbay, BC, Canada
  • Paula yu
    Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, WA, Australia
    Lions Eye Institute, University of Western Australia, Perth, WA, Australia
  • Yifan Jian
    School of Engineering Science, Simon Fraser University, Burnbay, BC, Canada
  • David Albiani
    Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada
  • Andrew Kirker
    Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada
  • Andrew Merkur
    Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada
  • Dao-Yi Yu
    Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, WA, Australia
    Lions Eye Institute, University of Western Australia, Perth, WA, Australia
  • Marinko V Sarunic
    School of Engineering Science, Simon Fraser University, Burnbay, BC, Canada
  • Footnotes
    Commercial Relationships Zaid Mammo, None; Chandra Bala, None; Jing Xu, None; Paula yu, None; Yifan Jian, None; David Albiani, None; Andrew Kirker, None; Andrew Merkur, None; Dao-Yi Yu, None; Marinko Sarunic, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 1647. doi:
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      Zaid Mammo, Chandra Bala, Jing Xu, Paula yu, Yifan Jian, David Albiani, Andrew Kirker, Andrew Merkur, Dao-Yi Yu, Marinko V Sarunic; Evaluating the Utility of Speckle-Variance Optical Coherence Tomography for Assessing the Human Macula. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1647.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

1) To demonstrate the utility of speckle variance optical coherence tomography (svOCT) for imaging human macular capillary networks. 2) To compare svOCT images of the macula with fluorescein angiography (FA) and histological images in a qualitative and quantitative manner.

 
Methods
 

A total of twelve eyes from six subjects had both svOCT and FA imaging. Manual tracing of macular vasculature images from the two modalities were performed and quantitative comparisons of capillary density was determined. Morphometric dimensions of the foveal avascular zone (FAZ) were quantified in 26 healthy human eyes after svOCT imaging. These results were compared to human histology data acquired from 11 cadaveric specimens.

 
Results
 

Mean age of subjects in the svOCT group and histology groups were 28.1 ± 4.6 and 45.2 ± 17.8 years (P < 0.001), respectively. Similar to histology, svOCT images were able to distinguish the inner and outer macular capillary networks (Figure 1). The svOCT images had an average capillary density of 31.2 ± 5.56 % versus19.3 ± 6.50 % for the FA group (p= < 0.001) (Figure 2). The reproducibility of this technique was high with no difference in density measurements between repeated tracings (P = 0.195). FAZ perimeter measurements were significantly greater in svOCT images (2.1 ± 0.4 vs. 1.6 ± 0.7 mm, P < 0.010) as were FAZ area measurements (0.3 ± 0.1 vs. 0.1 ± 0.1 mm2, P < 0.010).

 
Conclusions
 

svOCT appears to be a useful technique for delineating the morphometric characteristics of capillary networks in the human macula. Advantages of this modality include its non-invasive nature and its capacity to isolate the inner and outer macular networks. It therefore has the potential to supplement FA in the assessment of the retinal vasculature. Further work is required to validate the utility of this device for managing patients with retinal microvascular diseases.  

 
Morphometric comparisons between svOCT and histology images of inner and outer macular capillary networks.
 
Morphometric comparisons between svOCT and histology images of inner and outer macular capillary networks.
 
 
Comparison between fluorescein angiography and svOCT images of the human macula with respective manual tracings.
 
Comparison between fluorescein angiography and svOCT images of the human macula with respective manual tracings.

 
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