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Javier Zarranz-Ventura, Pearse Andrew Keane, Dawn A Sim, Victor Llorens, Anna Sala-Puigdollers, Jessica Matas, Marina Mesquida, Blanca Molins, Maite Sainz De La Maza, Alfredo Adan Civera; Validation of objective measurement of vitreous inflammation using Spectral Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1648.
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© ARVO (1962-2015); The Authors (2016-present)
To validate a proposed method for objective measurement of vitreous inflammation using a different Spectral Domain Optical Coherence Tomography (SD-OCT) device (Cirrus HD-OCT, Carl Zeiss Meditec, Dublin, CA) in a larger cohort of patients.
Observational, single-center cohort study. 56 uveitis eyes (56 patients) seen in a single tertiary referral uveitis unit (Institut Clinic d'Oftalmologia, ICOF, Hospital Clinic, Barcelona) were included in the study. Clinical data collected included visual acuity, diagnosis, phakic status and activity of uveitis as per standardized criteria (anterior chamber cell score and vitreous haze score, VHS). SD-OCT images captured at the same time than the clinical examination were analyzed using custom software, which provided absolute measurements of vitreous signal intensity which was then compared with that of the retinal pigment epithelium to generate an optical density ratio with arbitrary units (VIT/RPE-Relative intensity), as previously described elsewhere.
The VIT/RPE-Relative intensity was significantly higher in eyes with vitritis (0.37±0.4) than eyes with no vitritis (0.34±0.1, p<0.001), as well as in eyes with active uveitis (0.38±0.4) than eyes with quiescent uveitis (0.34±0.1, p<0.001). The VIT/RPE-Relative intensity showed a significant positive correlation with VHS (r=0.587, p<0.001). Significant differences were also observed between the different VHS groups with regards to the VIT/RPE-Relative intensity (p<0.001).
The results of this study support the previously proposed method for objective measurement of vitreous inflammation using SD-OCT, and achieves similar outcomes analyzing images captured with a different SD-OCT device in a larger cohort of patients. These findings suggest that the VIT/RPE-Relative intensity determination may be employed in future clinical trials as an objective, quantitative disease activity endpoint.
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