June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Validation of objective measurement of vitreous inflammation using Spectral Domain Optical Coherence Tomography
Author Affiliations & Notes
  • Javier Zarranz-Ventura
    Hospital Clinic de Barcelona, Barcelona, Spain
    Medical Retina & Uveitis, Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom
  • Pearse Andrew Keane
    Medical Retina & Uveitis, Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom
    NIHR Biomedical Research Center for Ophthalmology at Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom
  • Dawn A Sim
    Medical Retina & Uveitis, Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom
    NIHR Biomedical Research Center for Ophthalmology at Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom
  • Victor Llorens
    Hospital Clinic de Barcelona, Barcelona, Spain
  • Anna Sala-Puigdollers
    Hospital Clinic de Barcelona, Barcelona, Spain
  • Jessica Matas
    Hospital Clinic de Barcelona, Barcelona, Spain
  • Marina Mesquida
    Hospital Clinic de Barcelona, Barcelona, Spain
  • Blanca Molins
    Hospital Clinic de Barcelona, Barcelona, Spain
  • Maite Sainz De La Maza
    Hospital Clinic de Barcelona, Barcelona, Spain
  • Alfredo Adan Civera
    Hospital Clinic de Barcelona, Barcelona, Spain
  • Footnotes
    Commercial Relationships Javier Zarranz-Ventura, None; Pearse Keane, None; Dawn Sim, None; Victor Llorens, None; Anna Sala-Puigdollers, None; Jessica Matas, None; Marina Mesquida, None; Blanca Molins, None; Maite Sainz De La Maza, None; Alfredo Adan Civera, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 1648. doi:
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      Javier Zarranz-Ventura, Pearse Andrew Keane, Dawn A Sim, Victor Llorens, Anna Sala-Puigdollers, Jessica Matas, Marina Mesquida, Blanca Molins, Maite Sainz De La Maza, Alfredo Adan Civera; Validation of objective measurement of vitreous inflammation using Spectral Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1648.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To validate a proposed method for objective measurement of vitreous inflammation using a different Spectral Domain Optical Coherence Tomography (SD-OCT) device (Cirrus HD-OCT, Carl Zeiss Meditec, Dublin, CA) in a larger cohort of patients.

 
Methods
 

Observational, single-center cohort study. 56 uveitis eyes (56 patients) seen in a single tertiary referral uveitis unit (Institut Clinic d'Oftalmologia, ICOF, Hospital Clinic, Barcelona) were included in the study. Clinical data collected included visual acuity, diagnosis, phakic status and activity of uveitis as per standardized criteria (anterior chamber cell score and vitreous haze score, VHS). SD-OCT images captured at the same time than the clinical examination were analyzed using custom software, which provided absolute measurements of vitreous signal intensity which was then compared with that of the retinal pigment epithelium to generate an optical density ratio with arbitrary units (VIT/RPE-Relative intensity), as previously described elsewhere.

 
Results
 

The VIT/RPE-Relative intensity was significantly higher in eyes with vitritis (0.37±0.4) than eyes with no vitritis (0.34±0.1, p<0.001), as well as in eyes with active uveitis (0.38±0.4) than eyes with quiescent uveitis (0.34±0.1, p<0.001). The VIT/RPE-Relative intensity showed a significant positive correlation with VHS (r=0.587, p<0.001). Significant differences were also observed between the different VHS groups with regards to the VIT/RPE-Relative intensity (p<0.001).

 
Conclusions
 

The results of this study support the previously proposed method for objective measurement of vitreous inflammation using SD-OCT, and achieves similar outcomes analyzing images captured with a different SD-OCT device in a larger cohort of patients. These findings suggest that the VIT/RPE-Relative intensity determination may be employed in future clinical trials as an objective, quantitative disease activity endpoint.  

 
Box and whisker plot illustrating vitreous signal intensity/retinal pigment epithelium relative intensity measurements using SD-OCT and their relationship with different vitreous haze scores determined by clinical examination. Horizontal lines within each box represent medians, whereas the end of the boxes are the upper and lower quartiles.
 
Box and whisker plot illustrating vitreous signal intensity/retinal pigment epithelium relative intensity measurements using SD-OCT and their relationship with different vitreous haze scores determined by clinical examination. Horizontal lines within each box represent medians, whereas the end of the boxes are the upper and lower quartiles.

 
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