June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Birefringence imaging of posterior pathologies by Jones matrix optical coherence tomography for posterior eye
Author Affiliations & Notes
  • Satoshi Sugiyama
    Computational Optics Group, University of Tsukuba, Tsukuba, Japan
    Engineering Department, Tomey Corporation, Nagoya, Japan
  • Young-Joo Hong
    Computational Optics Group, University of Tsukuba, Tsukuba, Japan
    Computational Optics and Ophthalmology Group, Tsukuba, Japan
  • Deepa Kasaragod
    Computational Optics Group, University of Tsukuba, Tsukuba, Japan
    Computational Optics and Ophthalmology Group, Tsukuba, Japan
  • Shuichi Makita
    Computational Optics Group, University of Tsukuba, Tsukuba, Japan
    Computational Optics and Ophthalmology Group, Tsukuba, Japan
  • Sato Uematsu
    Department of Ophthalmology, Osaka University Medical School, Suita, Japan
  • Masahiro Miura
    Department of Ophthalmology, Tokyo Medical University Ibaraki Medical Center, Ami, Japan
  • Yasushi Ikuno
    Department of Ophthalmology, Osaka University Medical School, Suita, Japan
  • Yoshiaki Yasuno
    Computational Optics Group, University of Tsukuba, Tsukuba, Japan
    Computational Optics and Ophthalmology Group, Tsukuba, Japan
  • Footnotes
    Commercial Relationships Satoshi Sugiyama, Tomey corporation (E); Young-Joo Hong, Tomey corporation (F), Topcon (F); Deepa Kasaragod, Tomey corporation (F), Topcon (F); Shuichi Makita, Tomey corporation (F), Tomey corporation (P), Topcon (F); Sato Uematsu, None; Masahiro Miura, Novartis (R); Yasushi Ikuno, None; Yoshiaki Yasuno, Tomey corporation (F), Tomey corporation (P), Topcon (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 1651. doi:
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    • Get Citation

      Satoshi Sugiyama, Young-Joo Hong, Deepa Kasaragod, Shuichi Makita, Sato Uematsu, Masahiro Miura, Yasushi Ikuno, Yoshiaki Yasuno; Birefringence imaging of posterior pathologies by Jones matrix optical coherence tomography for posterior eye. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1651.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

Various case series of posterior diseases examined by a new type of polarization sensitive optical coherence tomography (PS-OCT), so called Jones matrix (JM-) OCT, is reported. JM-OCT provides standard OCT, polarization sensitive OCT, and OCT angiography by a single scan. The clinical utility of this new system is discussed by showing several cases including exudative macular diseases, pathologic myopia and glaucoma.

 
Methods
 

42 eyes of 27 subjects were enrolled, which include pathologic myopia (17 cases), choroidal neovascularization (CNV, 21 cases) and glaucoma (4 cases). The eyes were scanned by a custom-built clinical prototype of posterior JM-OCT with a probe wavelength of 1060 nm and a probe power of 1.3 mW. The measurement was performed with 512 A-scan x 256 B-scans x 4 frames covering a 6 mm x 6mm with 100,000 A-scan rate in 6.6 second. Scattering OCT and birefringence images obtained by JM-OCT were compared with standard imaging modality.

 
Results
 

Figure. 1 is the example of myopic CNV. The hyperscattering is consistently appeared both in the color fundus (a) and the en-face OCT (b). In the right side of B-scan image of scattering OCT (c), a hyper-scattering mass is observed (white arrow) which indicates fibrosis. Birefringence imaging (d) visualized the complex regional difference in the fibrosis (dark blue to green). Similar result was observed in 10 eyes. In the left side of tomographies (yellow arrow), sclera with uniform hyper-scattering in (c) is clearly visualized with layered structure which has different birefringence among layers in (d). It was found in 20 eyes.<br /> Figure 2 shows an optic nerve head (ONH) of a glaucomatous eye. En-face OCT (b) visualized peripapillary atorophy (PPA) which shows hyperscattering. This is consistent with color fundus (a) as indicated by yellow line. In C-scan slices of birefringence tomography at two different depths [(c) and (d)], sclera in PPA and around ONH showed high birefringence (white arrow). It would be an indicator of high density concentration of collagen. Similar result was found in 11 eyes.

 
Conclusions
 

Pathologic characteristics of macular disease and sclera were visualized by JM-OCT.  

 

 
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