June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Extended depth-of-focus contact lenses can slow the rate of progression of myopia
Author Affiliations & Notes
  • Ravi Chandra Bakaraju
    Brien Holden Vision Institute, Sydney, NSW, Australia
  • Pauline Xu
    Brien Holden Vision Institute, Sydney, NSW, Australia
    Brien Holden Vision Institute, Guangzhou, China
  • Xiang Chen
    Brien Holden Vision Institute, Guangzhou, China
  • Martin Ma
    Brien Holden Vision Institute, Guangzhou, China
  • Stephanie Song
    Brien Holden Vision Institute, Guangzhou, China
  • Monica Jong
    Brien Holden Vision Institute, Sydney, NSW, Australia
    Brien Holden Vision Institute, Guangzhou, China
  • Wayne Li
    Brien Holden Vision Institute, Guangzhou, China
  • Serge Resnikoff
    Brien Holden Vision Institute, Sydney, NSW, Australia
    School of Optometry and Vision Science, UNSW, Sydney, NSW, Australia
  • Brien A Holden
    Brien Holden Vision Institute, Sydney, NSW, Australia
    School of Optometry and Vision Science, UNSW, Sydney, NSW, Australia
  • Footnotes
    Commercial Relationships Ravi Bakaraju, WO2013/149303 A1, US 2013/0278888 A1 (P); Pauline Xu, Brien Holden Vision Institute (E); Xiang Chen, Brien Holden Vision Institute (E); Martin Ma, Brien Holden Vision Institute (E); Stephanie Song, Brien Holden Vision Institute (E); Monica Jong, Brien Holden Vision Institute (E); Wayne Li, Brien Holden Vision Institute (E); Serge Resnikoff, Brien Holden Vision Institute (C); Brien Holden, Brien Holden Vision Institute (E), WO2013/149303 A1 (P)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 1728. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Ravi Chandra Bakaraju, Pauline Xu, Xiang Chen, Martin Ma, Stephanie Song, Monica Jong, Wayne Li, Serge Resnikoff, Brien A Holden, ; Extended depth-of-focus contact lenses can slow the rate of progression of myopia. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1728.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: We investigated the effects of two different, novel design, extended depth-of-focus (EDOF) contact lenses (CL) and a commercially-available single vision control CL on the rate of myopia progression in Chinese children.

Methods: A prospective, double-masked, randomized clinical trial was initiated at the BHVI China research clinic in January 2014 to enrol 270 Chinese children, aged 8 to 13 years, with spherical equivalent refractive error between -0.75D and -3.50D. Enrolled patients were randomized into one of the following: a single vision control CL, EDOF1 or EDOF2 prototype CL. The primary outcome measures, cycloplegic autorefraction (AR, Shin-Nippon, Japan) and axial length (AL, Lenstar, Switzerland), were measured at baseline, and were scheduled to be measured every 6 months for at least 3 years. Each group was matched for age, gender, parental myopia, AL and refractive error. Exclusion criteria included previous treatment for myopia and systemic or ocular disease.

Results: To date, approximately twenty children in each group have completed the 6 months visit. The mean rate of myopia progression for the control group was AR: -0.49D ± 0.29 and AL: 0.17mm ± 0.09. Statistically significant reduction in the rate of myopia progression (p<0.001) was achieved in children wearing both types of EDOF lenses; EDOF1: AR -0.24D ± 0.28 (51% reduction) and AL 0.07 mm ± 0.08 (58% reduction); EDOF2: AR -0.23D ± 0.28 (53% reduction) and AL 0.08 mm ± 0.09 (53% reduction). The outcome measures obtained with two EDOF lenses were not significantly different between eachother (p>0.05).

Conclusions: The EDOF lenses significantly slowed the rate of progression of myopia in children. Longer term results with greater number of participants will be needed to substantiate the results obtained at the 6-month visit.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×