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Franck Fajnkuchen, Lise Qu, Valerie Sarda, Gilles Chaine, Audrey Giocanti-Auregan; Impact of serous retinal detachment on the efficacy of ranibizumab therapy in diabetic macular edema. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1756.
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© ARVO (1962-2015); The Authors (2016-present)
To describe the evolution of diabetic macular edema (DME) treated with ranibizumab with regard to the presence of serous retinal detachment (SRD).
Diabetic patients treated with ranibizumab for DME were enrolled retrospectively. Patients were classified according to their optical coherence tomography (OCT) findings as follows: group 1 with SRD (G1) and group 2 without SRD (G2). Primary outcome was to assess the mean change in best-corrected visual acuity (BCVA) in letter score from baseline to month 6. Secondary outcomes were to determine the mean central retinal thickness (CRT) change, total number of intravitreal injections, proportion of good responders (BCVA gain ≥5 letters with CRT <300 μm with a restoration of foveal pit) and poor responders (loss of BCVA ≥5 letters and CRT >300 μm).
48 eyes with DME were included: 23 eyes in G1 and 25 eyes in G2. The proportion of SDR was 47.9%. Mean change BCVA was significantly greater in G1 than in G2: +21 ± 16.5 letters versus +7.8 ± 10.2 letters (p=0.002) from baseline to month 6. The mean CRT change was -339 ± 278 μm in G1 and -146 ± 136 μm in G2 (p=0.003). Mean injection number was 4.3 in G1 and 4.2 in G2 (p>0.05). Proportion of good responders was 65% in G1 versus 20% in G2 (p=0.002). Proportion of poor responders was similar (8.7% versus 12%, p=0.7).
In DME, the presence of SRD seems to be associated with a good response to ranibizumab.
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