June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Full-field Stimulus Threshold (FST) Changes After Intravitreal Ranibizumab and Single or Multiple Spot Panphotocoagulation in Proliferative Diabetic Retinopathy
Author Affiliations & Notes
  • Andre Messias
    Ophthalmology, University of Sao Paulo, Ribeirao Preto, Brazil
  • Katharina Messias
    Ophthalmology, University of Sao Paulo, Ribeirao Preto, Brazil
  • Rafael de Montier Barroso
    Ophthalmology, University of Sao Paulo, Ribeirao Preto, Brazil
  • Amanda Marega
    Ophthalmology, University of Sao Paulo, Ribeirao Preto, Brazil
  • Rodrigo Jorge
    Ophthalmology, University of Sao Paulo, Ribeirao Preto, Brazil
  • Footnotes
    Commercial Relationships Andre Messias, None; Katharina Messias, None; Rafael de Montier Barroso, None; Amanda Marega, None; Rodrigo Jorge, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 1776. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Andre Messias, Katharina Messias, Rafael de Montier Barroso, Amanda Marega, Rodrigo Jorge; Full-field Stimulus Threshold (FST) Changes After Intravitreal Ranibizumab and Single or Multiple Spot Panphotocoagulation in Proliferative Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1776.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: To describe changes on full-field stimulus threshold (FST) after one-year treatment with intravitreal ranibizumab (IVR) associated to panphotocoagulation (PRP), using single (EDTRS) or multiple spot (PASCAL) for proliferative diabetic retinopathy (PDR).

Methods: Randomized, prospective clinical trial. Patients were assigned to treatment with only IVR, PASCAL or EDTRS. PRP was performed exclusively at baseline in 2 sessions. In eyes with macular edema, macular short-pulse grid laser was associated to IVR at baseline. IVR was repeated monthly if central subfield macular thickness (CSMT) measured with SDOCT was higher than 300 µm, or quarterly if neovascularization was detected by angiography. Comprehensive ophthalmological evaluations, including best-corrected visual acuity (BCVA) measurement, OCT to determine central subfield macular thickness were performed at baseline and every 4 weeks. FST was performed after 25 minutes dark adaptation, using Espion E2 system with the ColorDome LED full-field stimulator (Diagnosys LLC, Lowell, MA), first using red (635 to 638 nm), then blue (465 to 470 nm), and then white (6500 K) stimulus, with 5 minutes inter-session interval, at baseline and one year after treatment.

Results: EDTRS n= 10; PASCAL n= 9; and IVR = 8 patients were evaluated with FST until week 48. No significant difference was observed between groups for CSMT, FST or BCVA at baseline. Within-group analysis showed significant lower CSMT in groups IVR and PASCAL at 48 weeks, but this was not observed for group EDTRS; and significant worsen FST was observed using blue, white and red stimuli at week 48 for EDTRS, but not for IVR or PASCAL. No significant correlations were found between FST and BCVA changes, and no significant changes were observed on between-group analysis.

Conclusions: Chromatic FST changes after PRP for PDR is certainly multifactorial, involving functional loss due to direct retinal damage and/or macular edema. These data suggest that PRP is associated with worsen FST after one year follow-up.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×