June 2015
Volume 56, Issue 7
ARVO Annual Meeting Abstract  |   June 2015
Sleep disorders : a risk factor of central serous chorioretinopathy
Author Affiliations & Notes
  • Mariam Dhundass
    ophthalmology, HOSPITAL HOTEL DIEU, Paris, France
  • elodie bousquet
    ophthalmology, HOSPITAL HOTEL DIEU, Paris, France
  • Mathieu Lehmann
    ophthalmology, HOSPITAL HOTEL DIEU, Paris, France
  • Pierre-Raphael Rothschild
    ophthalmology, HOSPITAL HOTEL DIEU, Paris, France
  • Antoine P Brezin
    ophthalmology, HOSPITAL HOTEL DIEU, Paris, France
  • Francine Behar Cohen
    Ophtalmology, Lausanne, Switzerland
  • Footnotes
    Commercial Relationships Mariam Dhundass, None; elodie bousquet, None; Mathieu Lehmann, None; Pierre-Raphael Rothschild, None; Antoine Brezin, None; Francine Behar Cohen, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 1799. doi:
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      Mariam Dhundass, elodie bousquet, Mathieu Lehmann, Pierre-Raphael Rothschild, Antoine P Brezin, Francine Behar Cohen; Sleep disorders : a risk factor of central serous chorioretinopathy. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1799.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: Based on clinical observation, we hypothesized that sleep disorders and staggered work hours are risk factors for central serous chorioretinopathy (CSC)

Methods: 38 patients with active acute CSC and 30 controls were included in this prospective case control study.The Insomnia Severity Index (ISI), a validate screening device for insomnia research, was administered to all the patients and controls with a cut off score of 10. The other risk factor (stress, steroids, profession, work shift) were measured with an additional questionnaire. Patients from two groups matched for age and sex.

Results: Mean age in CSC group was 44±8,5 versus 42±10,2 years in the control group (p=0.4). 84% and 80% of patients were male in CRSC and control group (p=0.8).<br /> An ISI score > 10 was found in 58% of patients with CSC compared to 17% in the control group (OR : 6,9 [2,25 ; 21] ; p=0.001). In CSC group, 45% of patients had staggered work hours compared to 10% in the control group (OR : 7,3 [2; 26,2] ; p=0.002). Steroids use was significantly increased in CSC patients as compared to controls (60,5% versus 26,7% , OR : 4,2 [1,5; 11,7] ; p=0.005) and stress was significantly more frequent in CSC patients (65% versus 13% OR : 12,5 [3,8; 41,4] ; p<0.001).

Conclusions: Sleep disorders, different from sleep apnea and staggered works hours could be newly identified risk factors for CSC. The relation between circadian rythm disruption, cortisol rythmicity and CSC should be analyzed.


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