June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Numerical simulations of flow and mass transport processes in the anterior chamber in the presence of an iris-fixated intraocular lens
Author Affiliations & Notes
  • Rodolfo Repetto
    Department of Civil, Chemical and Environmental engineering, University of Genoa, Genoa, Italy
  • Peyman Davvalo Khongar
    Department of Civil, Chemical and Environmental engineering, University of Genoa, Genoa, Italy
  • Jan Oscar Pralits
    Department of Civil, Chemical and Environmental engineering, University of Genoa, Genoa, Italy
  • Jennifer Helen Siggers
    Department of Bioengineering, Imperial College London, London, United Kingdom
  • Paolo Soleri
    Ophtec BV, Groningen, Netherlands
  • Footnotes
    Commercial Relationships Rodolfo Repetto, Ophtec BV (F); Peyman Davvalo Khongar, None; Jan Pralits, Ophtec BV (F); Jennifer Siggers, Ophtec BV (F); Paolo Soleri, Ophtec BV (E)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 1898. doi:
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      Rodolfo Repetto, Peyman Davvalo Khongar, Jan Oscar Pralits, Jennifer Helen Siggers, Paolo Soleri; Numerical simulations of flow and mass transport processes in the anterior chamber in the presence of an iris-fixated intraocular lens. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1898.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: In this study we investigated how implantation of iris-fixated intraocular lenses (IOLs) affects aqueous humor flow characteristics and mass transport processes in the anterior chamber. Specifically, we studied changes in the wall shear stress distribution and oxygen/nutrient availability on the cornea, after lens implantation.

Methods: We adopted a mathematical model to study aqueous flow and oxygen/nutrient concentration distribution in the anterior chamber in the presence of an iris-fixated IOL. Numerical solutions on idealized but realistic geometries were obtained employing the open source software OpenFOAM. The validity of the numerical results were confirmed by analytical solutions obtained through a simplified model based on the lubrication theory. We considered various mechanisms that generate aqueous flow in the anterior chamber and focused, in particular, on the production/drainage flow and the thermal flow generated by a temperature gradient across the anterior chamber.

Results: The model provides a detailed description of the velocity, pressure and concentration distribution in the anterior chamber, both in the presence and absence of the IOL. Results show that changes in fluid pressure after implantation of the IOL are negligible. Wall shear stress distribution and mass transport processes in the anterior chamber are significantly modified by the presence of the IOL. However, the maximum wall shear stress on the cornea does not grow after IOL implantation.

Conclusions: The study sheds some light on the changes induced by implantation of an iris-fixated IOL on fluid flow and mass transport in the anterior chamber, an information that would be difficult to obtain without making use of a mathematical model. Results suggest that changes in the wall shear stress, albeit significant, are unlikely to be the cause of the complications associated with the use of iris-fixated IOLs.

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