June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Prevalence and Incidence of Cataracts in a Population of Yucatan Miniswines after Induction of Type I Diabetes: a Model for Preventative or Therapeutic Cataract Therapies
Author Affiliations & Notes
  • Alain Stricker-Krongrad
    Sinclair Research Center, L.L.C., Columbia, MO
  • Chris Hanks
    Sinclair Research Center, L.L.C., Columbia, MO
  • Melissa Freeman
    Sinclair Research Center, L.L.C., Columbia, MO
  • Sarah Schlink
    Sinclair Research Center, L.L.C., Columbia, MO
  • Lauren Delaney
    Sinclair Research Center, L.L.C., Columbia, MO
  • Jason Liu
    Sinclair Research Center, L.L.C., Columbia, MO
  • Armando Tellez Cruz
    Alizee Pathology, LLC, Thurmont, MD
  • Joan Wicks
    Alizee Pathology, LLC, Thurmont, MD
  • Serge Rousselle
    Alizee Pathology, LLC, Thurmont, MD
  • Guy Bouchard
    Sinclair Research Center, L.L.C., Columbia, MO
  • Footnotes
    Commercial Relationships Alain Stricker-Krongrad, None; Chris Hanks, None; Melissa Freeman, None; Sarah Schlink, None; Lauren Delaney, None; Jason Liu, None; Armando Cruz, None; Joan Wicks, None; Serge Rousselle, None; Guy Bouchard, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 1900. doi:
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      Alain Stricker-Krongrad, Chris Hanks, Melissa Freeman, Sarah Schlink, Lauren Delaney, Jason Liu, Armando Tellez Cruz, Joan Wicks, Serge Rousselle, Guy Bouchard; Prevalence and Incidence of Cataracts in a Population of Yucatan Miniswines after Induction of Type I Diabetes: a Model for Preventative or Therapeutic Cataract Therapies. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1900.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

Cataracts as a consequence of chronic diabetes is considered a leading cause of legal blindness in humans in the United States and is also observed frequently in aged diabetic populations (>65%).<br /> Assess post-induction (PI) onset of clinical ocular cataract(s) in a colony of over 266 castrated, male, diabetic, Yucatan miniature swine.

 
Methods
 

Diabetic miniature swine were routinely screened by a veterinarian for clinical ocular abnormalities including visible ‘mature’ cataracts.

 
Results
 

Over the course of a 6 month period, the prevalence was 30% (80 positive animals out of 266 animals). The most recent incidence (past 2.5 months) was 20.4% (38 positive animals with 60 affected eyes from pool of 186 previously negative animals). Eighteen animals had bilateral and 20 animals had unilateral cataracts (OD: 31; OS: 29). Cataract onset ranged from 2 to 19 months PI with an average of 11 months PI. Cataracts were detected earlier in animals when euglycaemia was intentionally less controlled, which supports the current predominant theory of glycation-induced cataract development. Interestingly, swine unlike human are not capable of glycating their hemoglobin due to the lack of penetration of glucose into the red cells. Miniswine with cataracts appear to function acceptably well despite the assumed visual handicap by relying on other senses.

 
Conclusions
 

Diabetic Yucatan miniature swine commonly manifest with cataracts on average at 11 months post-induction. Insulin regimen and glucose control are strong factors in the prevalence and incidence of cataracts in diabetic miniswines. Our data also suggests that the glycation of swine lenses readily occurs due to the high incidence of cataracts in diabetic animals with non-optimal glucose control. In addition the diabetic miniswine would provide a good model for preventative or therapeutic cataract therapies.  

 
Diabetic Yucatan Miniswine, Saggital Section of Pathological Lens with Cataractous Nuclear and Cortical Area.
 
Diabetic Yucatan Miniswine, Saggital Section of Pathological Lens with Cataractous Nuclear and Cortical Area.
 
 
Diabetic Yucatan Cataract Lens Detail.<br /> *Solid arrowheads=bladder cells (hydropic degeneration of lens fiber cells)<br /> *Arrows=Morgagnian globules (bright pink aggregates of denatured lens protein)<br /> *Double arrow=fibroblastic metaplasia of the anterior lens epithelium<br /> *Clear arrowhead=slight reactive hyperplasia of the lens epithelium<br />
 
Diabetic Yucatan Cataract Lens Detail.<br /> *Solid arrowheads=bladder cells (hydropic degeneration of lens fiber cells)<br /> *Arrows=Morgagnian globules (bright pink aggregates of denatured lens protein)<br /> *Double arrow=fibroblastic metaplasia of the anterior lens epithelium<br /> *Clear arrowhead=slight reactive hyperplasia of the lens epithelium<br />

 
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