June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
The United Kingdom Diabetic Retinopathy Electronic Medical Record (UK DR EMR) Users Group:Report 2 - real world data for diabetic macular edema and impact of cataract surgery from 20 United Kingdom hospital eye services
Author Affiliations & Notes
  • Alastair K Denniston
    Ophthalmology, University Hospitals Birmingham NHSFT, Birmingham, United Kingdom
    Academic Unit of Ophthalmology, University of Birmingham, Birmingham, United Kingdom
  • Haogang Zhu
    Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom
    City University London, London, United Kingdom
  • Aaron Lee
    City University London, London, United Kingdom
    University of British Columbia, Vancouver, BC, Canada
  • David Paul Crabb
    City University London, London, United Kingdom
  • Adnan Tufail
    Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom
  • Catherine A Egan
    Moorfields Eye Hospital, London, United Kingdom
  • Robert Johnston
    Gloucestershire Hospitals NHS Foundation Trust, Gloucester, United Kingdom
  • Footnotes
    Commercial Relationships Alastair Denniston, None; Haogang Zhu, None; Aaron Lee, None; David Crabb, None; Adnan Tufail, Novartis (F); Catherine Egan, Allergan (C), Novartis (F); Robert Johnston, Alimera Science (C), Allergan (C), Bayer (C), Medisoft (E), Novartis (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 2019. doi:
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      Alastair K Denniston, Haogang Zhu, Aaron Lee, David Paul Crabb, Adnan Tufail, Catherine A Egan, Robert Johnston, ; The United Kingdom Diabetic Retinopathy Electronic Medical Record (UK DR EMR) Users Group:Report 2 - real world data for diabetic macular edema and impact of cataract surgery from 20 United Kingdom hospital eye services. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):2019.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: Cataract surgery is associated with increased inflammatory mediators, and other retinovascular changes that might increase risk of developing diabetic macular edema (DME) after cataract surgery. We wished to assess the rate of developing DME requiring treatment with intravitreal ranibizumab and the possible impact of cataract surgery in a large cohort for which there was a single electronic platform for capturing data consistently.

Methods: Multicentre national DR database study with 3458 eyes receiving ranibizumab for DME. Data collected in the course of routine clinical care , anonymised data within an electronic medical record system were extracted remotely from 20 Centres. The minimum dataset included: age, visual acuity at baseline and at all subsequent visits, injection episodes, and timing of cataract surgery. Main Outcome Measures: Rate of developing 'injection-requiring DME' in relation to timing of cataract surgery in the same eye.

Results: The follow-up period was median [IQR] 1 [0.2,2.3] years. During this period, 469 eyes underwent cataract surgery. The rate of developing 'injection-requiring DME' in this cohort decreased prior to surgery (3.5% for the period 12-9mths prior, 2.4% for 9-6mths prior, 2.3% for 6-3mths prior and 1.3% for 3-0mths prior), but increased sharply after surgery, peaking in the 3-6mths period (9.1% for the 0-3mths period post-op, 12.3% for 3-6mths post-op, 8.5% for 6-9 mths post-op and 5.7% for 9-12mths post-op).

Conclusions: This real world dataset achieved at a large number of centres across the UK suggests that there may be an increased rate of developing DME requiring treatment with intravitreal ranibizumab. An alternative explanation is that this is purely an issue of visualization, however in the UK access to ranibizumab for DME is based on a minimum OCT-measured central macular thickness, increasing the likelihood that our findings represent a real effect of cataract surgery on DME, rather than being due to improved visualisation alone. It is also possible that this post-operative peak may be compounded by post-operative CME in this relatively high-risk group, and this is the subject of on-going investigation.

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