Purchase this article with an account.
Zhiyong Yang, Andrew J Tatham, Naama Hammel, Lucie Sharpsten, Felipe A Medeiros, Robert N Weinreb, Christopher A Girkin, Jeffrey M Liebmann, Linda M Zangwill; Ganglion cell and retinal nerve fiber layer thickness predict the development of visual field damage in glaucoma suspects. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):2054.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To compare baseline macular ganglion cell plus inner plexiform layer (mGCIPL) thickness and circumpapillary retinal nerve fiber layer (cpRNFL) thickness as predictors of visual visual field loss in glaucoma suspects.
This is a prospective, observational cohort study. Glaucoma suspects were defined as having suspicious glaucomatous optic disc appearance or ocular hypertension (intraocular pressure, > 21 mmHg) without repeatable standard automated perimetry (SAP) at baseline, from Diagnostic Innovations in Glaucoma Study and African Descent and Glaucoma Evaluation Study.Baseline mGCIPL thickness was measured using Cirrus optical coherence tomography (OCT) and baseline cpRNFL thickness measured using Spectralis spectral domain OCT (SD-OCT). The association between baseline mGCIPL or cpRNFL thicknesses and the development of 3 consecutive visual field damage (VFD) was determined by Cox proportional hazard univariate and multivariate models.
106 subjects (149 eyes) met the eligibility criteria. The mean number of visits was 5.6 ± 1.9 visits over a mean follow-up time of 2.25 ± 0.62 years. 23 eyes (15.4%) eyes developed a repeatable VFD during follow-up. In multivariate models, thinner baseline average and sectoral mGCIPL and cpRNFL were associated with the development of visual field damage, with HRs (95%CI) per 10μm thinner ranging from 1.65 (1.09, 2.50) for minimum mGCIPL thickness to 2.82 (1.54, 5.17) for average mGCIPL thickness, and 1.68 (0.96, 2.94) for average cpRNFL thickness and 1.71 (1.15, 2.54) for temporal cpRNFL thickness. No significant differences were found between c-indices calculated for mGCPIL and cpRNFL multivariate models.
Thinner mGCIPL and cpRNFL measurements at baseline have similar predictive abilities for the development of repeatable VFD among glaucoma suspects. Our results suggest that baseline mGCIPL and cpRNFL thickness measurements are useful in identifying glaucoma suspects who are at higher risk for progression to visual field damage.
This PDF is available to Subscribers Only