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Line AZOULAY, Philippe Chaumet-Riffaud, Naomi Berdugo, Isabelle S Audo, José Sahel, Saddek Mohand-Said; Impact of visual field and acuity loss on the quality of life and the emotional state of patients with Retinitis Pigmentosa.. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):2120.
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© ARVO (1962-2015); The Authors (2016-present)
Retinitis Pigmentosa (RP) represents a group of inherited retinal diseases inducing photoreceptor degeneration, leading to progressive visual loss.<br /> The objective of this study is to evaluate the impact of the visual loss on the quality of life and the emotional state of patients affected by RP.
Cross-sectional study with 60 patients with typical RP and 20 healthy volunteers. Functional ocular evaluations were performed including binocular visual field assessment with Goldmann’s perimetry and measuring visual acuity with ETDRS scale. At the same time, the scores of self-reported NEI-VFQ 25 and HADS for the Anxiety/Depression assessment were collected. The RP population was divided into three groups according to visual field impairment in the first part of the study and into three groups according to the level of visual acuity in the second part.<br /> We compared the scores of quality of life and emotional states between the different groups of patients (visual-field and visual acuity) and the control group. Non parametric tests were used and global alpha risk at 0.05 was specified.
Significant difference was revealed for Composite Score between groups of visual field (VF) impairment (p<0.001) showing a statistically proven difference between group I (ØVF<20°) and GII (20°≤ØVF≤40°) (p=0.013) and between group III (ØVF>40°) and control group (p<0.001). Concerning groups of visual acuity (VA) assessment, a significant difference was showed for composite score between group A (VA<0.3) and group B (0.30.7) and control group (p<0.001).<br /> For anxiety and depression scores, in VF-groups and VA-groups, by comparing inter-group scores, it is shown that there is no significant difference between the retinitis pigmentosa groups, but only between the control group and the most affected groups.
A significant deterioration in the quality of life with a significant impact on the emotional state is noted in patients with RP with a diameter of residual visual field of less than 20 degrees and visual acuity of less than 0.3. These thresholds could represent minimal therapeutic effects that have to be targeted by the therapies aiming at visual restoration, or be not reached by those aiming at preservation. Translating a functional benefit, induced by a therapeutic action in terms of improvement of QoL, is indeed determinant.
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