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Haoyu Chen, Shaofen Huang, Zhen Li, Zhihao Lu; Inhibition of subretinal neovascularization in Vldlr knockout mice by anti-VEGF agents. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):2358.
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© ARVO (1962-2015); The Authors (2016-present)
Vldlr knockout mice is characterized by subretinal neovascularization which mimics wet age-related macular degeneration in human. The purpose of this study is to investigate the effects of two anti-VEGF agents, Conbercept and Ranibizumab on subretinal neovascularization in Vldlr knockout mice.
Six vldlr knockout mice were treated with intravitreal administration of 10ug/1ul conbercept or 10ug/1ul Ranibizumab in the right eyes. The left eyes served as control. Fluorescein angiography was performed before, 3 days and 7 days after administration of drugs. The area of fluorescein leakage was quantified using Image J software and compared.
The area of subretinal neovascularization reduced to 73% and 36% in the eyes treated with Conbercept at 3 days and 7 days. The area of subretinal neovascularization in the eyes treated with Ranibizumab reduced to 42% and 33% at 3 and 7 days respectively.
Both Conbercept and ranibizumab inhibits subretinal neovascularization in Vldlr knockout mice.
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