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Yousef A Alghamdi, Nabeel M Shalabi, Allison Louise McClellan, Anat Galor; Meibomian gland dysfunction and hypercholesterolemia. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):2505.
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© ARVO (1962-2015); The Authors (2016-present)
To study the relationship between meibomian gland parameters and systemic lipid levels in an elderly, predominantly male population.
Patients with normal eyelid and corneal anatomy were prospectively recruited from the Miami VAMC eye clinic. Patients underwent a complete ocular surface examination including assessment of meibomian gland (MG) parameters. The main outcome measures were the correlations between meibomian gland parameters and systemic lipid levels.
The mean age of the 136 patients was 65 (standard deviation 11); 90% were male, 52% white, and 30% Hispanic. A large percentage of the population (86%, n=117) had abnormal MG parameters defined as a score of 2 or greater (in the more severely affected eye) on any of the studies MG parameters (by subtype: vascularity 19%, plugging 69%, drop-out 48%, abnormal quality 60%). All associations between MG parameters and systemic lipid layers (total cholesterol, high-density lipoprotein, low-density lipoprotein, triglycerides) were weak and most were not significant. The only significant association was a negative one between triglyceride levels and meibum quality (Spearman’s rho -0.19, p-value=0.03).
Meibomian gland dysfunction is a frequent finding in an elderly, predominantly male population and does not seem to be related to systemic lipid levels.
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