June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Hyperopic Refractive Error and the Risk of Age-related Macular Degeneration in the South Korean Population
Author Affiliations & Notes
  • Daniel L Chao
    Ophthalmology, University of California, San Francisco, San Francisco, CA
  • Shuai-Chun Lin
    Ophthalmology, University of California, San Francisco, San Francisco, CA
  • Shan C Lin
    Ophthalmology, University of California, San Francisco, San Francisco, CA
  • Footnotes
    Commercial Relationships Daniel Chao, None; Shuai-Chun Lin, None; Shan Lin, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 2570. doi:
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      Daniel L Chao, Shuai-Chun Lin, Shan C Lin; Hyperopic Refractive Error and the Risk of Age-related Macular Degeneration in the South Korean Population . Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):2570.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To investigate the association between refractive error and the likelihood of having age-related macular degeneration (AMD) in the South Korean population

 
Methods
 

Data were included from 14,352 participants who were 40 years and older with gradable fundus photographs in the 2008-2011 Korean National Health and Nutrition Examination Survey, a cross-sectional population study. Early and late AMD status was graded based on the International Age-related Maculopathy Epidemiological Study Group grading system. Autorefraction data was collected to calculate spherical equivalent refraction in diopters, and further graded into four groups: hyperopia (≥1.0D), emmetropia (-0.99D to 0.99D), mild myopia (-1.0D to -2.99D), and moderate to high myopia (≥-3.0D). Demographic, comorbidity, and health-related behavior information was obtained via interview.

 
Results
 

Hyperopic and emmetropic groups were significantly associated with higher odds of all and early AMD after adjustment for covariates while comparing with moderate to myopia group (for all AMD: odds ratio [OR] 2.3, 95% confidence interval [CI] 1.17-4.51 for hyperopic group; OR 2.08, 95% CI 1.08-3.99 for emmetropic group; for early AMD: OR 2.67, 95% CI 1.23-5.78 for hyperopic group; OR 2.41, 95% CI 1.13-5.15 for emmetropic group).<br /> <br /> Each diopter increase in hyperopic refraction was associated with a 15% (OR 1.15, 95% CI 1.07-1.24) and 17% (OR 1.17, 95% CI 1.08-1.26) increased risk of all and early AMD, respectively, after adjustment for confounders. After further stratifying into two age groups (40-59 year-old and ≥60 year-old), hyperopic status was still significantly associated with all and early AMD in all age groups, while mild myopia and emmetropia groups were also significantly associated with early AMD in subjects 60 years and older.<br /> <br /> No significant association between refractive status and the diagnosis of late AMD was noted.

 
Conclusions
 

Hyperopic and emmetropic refractive status were associated with greater odds of all and early AMD diagnosis in a representative sample of the South Korean population.

 
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