June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Susceptibility and resistance of Staphylococcus epidermidis ocular strains in a Hispanic population.
Author Affiliations & Notes
  • Jaime Torres
    Ophthalmology Institute, Tecnologico de Monterrey, Monterrey, Mexico
  • Alejandro Fernando Ibarra-Lozano
    Ophthalmology Institute, Tecnologico de Monterrey, Monterrey, Mexico
  • Pedro Mario Gonzalez
    Ophthalmology Institute, Tecnologico de Monterrey, Monterrey, Mexico
  • Jorge E Valdez
    Ophthalmology Institute, Tecnologico de Monterrey, Monterrey, Mexico
    Ophthalmology Research Chair. School of Medicine and Health Sciences, Tecnologico de Monterrey, Monterrey, Mexico
  • Footnotes
    Commercial Relationships Jaime Torres, None; Alejandro Ibarra-Lozano, None; Pedro Gonzalez, None; Jorge Valdez, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 267. doi:
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    • Get Citation

      Jaime Torres, Alejandro Fernando Ibarra-Lozano, Pedro Mario Gonzalez, Jorge E Valdez; Susceptibility and resistance of Staphylococcus epidermidis ocular strains in a Hispanic population.. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):267.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To identify the pattern of susceptibility of ocular Staphylococcus epidermidis strains to antibiotics in the Northeast region of Mexico in order to offer most effective treatments for ocular infections.

Methods: This is an observational retrospective series of cases study of the microbiological cultures obtained from different ocular sites in which S. epidermidis was isolated, in the Microbiology Department of Hospital San Jose, Tecnologico de Monterrey, Mexico. The time lapse studied was from January 2002 to December 2012. A total of 62 positive cultures for S. epidermidis were obtained, in which antibiotic testing was reported as susceptible or resistant with the results expressed as percentages. Classifications for the antibiotics were made according to the Minimum Inhibitory Concentration (MIC) reported by the Microbiology Department.

Results: A total of 62 eyes were included in the study. The average age of the patients was 28.5 (range 0-79 years old). The most effective antibiotics according to the percentage of the susceptible strains were: Rifampin 100%, Vancomycin 97%, Trimethoprim-Sulfamethoxazole 82%. The most potent antibiotics according to the MIC average of susceptible cases: Oxacilin 0.3 mg/mL, Clindamycin 0.41 mg/mL, and Erythromycin 0.6 mg/mL. The most common sites of sample isolation were: eye secretion (72.4%, 45 cases), vitreous (9.6%, 6 cases), and corneal ulcer (4.8%, 3 cases). A smaller number of samples were collected from corneal scrape, eyelid border, contact lens, conjunctiva, and aqueous humor.

Conclusions: The most effective antibiotic against Staphiloccoccus epidermidis isolated from ocular infection sites in the Northeast of Mexico was Oxacilin, followed by Clindamycin and Erythromycin. This is the first study to determine ocular S. epidermidis susceptibility to antibiotics in our population. The results obtained from this research, will allow to offer most effective treatment for ocular infections.

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