June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Preperimetric glaucoma pathophysiological study part1:Twelve-month results of topical prostaglandin analogues
Author Affiliations & Notes
  • Naoko Aizawa
    Tohoku University, Sendai, Japan
  • Hiroshi Kunikata
    Tohoku University, Sendai, Japan
  • Satoru Tsuda
    Tohoku University, Sendai, Japan
  • Yukihiro Shiga
    Tohoku University, Sendai, Japan
  • Yukiko Maiya
    Tohoku University, Sendai, Japan
  • Naoki Kiyota
    Tohoku University, Sendai, Japan
  • Kazuko Omodaka
    Tohoku University, Sendai, Japan
  • Yu Yokoyama
    Tohoku University, Sendai, Japan
  • Morin Ryu
    Tohoku University, Sendai, Japan
  • Toru Nakazawa
    Tohoku University, Sendai, Japan
  • Footnotes
    Commercial Relationships Naoko Aizawa, Santen Pharmaceutical Co. Ltd (F); Hiroshi Kunikata, Santen Pharmaceutical Co. Ltd (F); Satoru Tsuda, Santen Pharmaceutical Co. Ltd (F); Yukihiro Shiga, Santen Pharmaceutical Co. Ltd (F); Yukiko Maiya, Santen Pharmaceutical Co. Ltd (F); Naoki Kiyota, santen (F); Kazuko Omodaka, Santen Pharmaceutical Co. Ltd (F); Yu Yokoyama, Santen Pharmaceutical Co. Ltd (F); Morin Ryu, Santen Pharmaceutical Co. Ltd (F); Toru Nakazawa, Santen Pharmaceutical Co. Ltd (F)
  • Footnotes
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Investigative Ophthalmology & Visual Science June 2015, Vol.56, 2750. doi:
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      Naoko Aizawa, Hiroshi Kunikata, Satoru Tsuda, Yukihiro Shiga, Yukiko Maiya, Naoki Kiyota, Kazuko Omodaka, Yu Yokoyama, Morin Ryu, Toru Nakazawa; Preperimetric glaucoma pathophysiological study part1:Twelve-month results of topical prostaglandin analogues. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):2750.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: A treatment plan has not been established in preperimetric glaucoma (PPG). We are investigating prospectively the response to topical prostaglandin analogues on microcirculation in eyes with PPG. Here, we report 12-month results on intraocular pressure (IOP) and optic nerve head (ONH) microcirculation in this study.

Methods: This study is prospective observational study. We collected 136 eyes with PPG of 136 patients (53.8 ± 14.3 years) treated with tafluprost. The IOP, mean blur rate (MBR) in the ONH, mean deviation (MD) and circumpapillary retinal nerve fiber layer thickness (cpRNFLT) were measured with Goldmann applanation tonometry, laser speckle flowgraphy (LSFG-NAVI), standard automated perimetry and optical coherence tomography, respectively, before and from 4 and 12 months after tafluprost administration.

Results: Before administration, IOP, MBR, MD and cpRNFLT were 16.5 ± 2.5mmHg, 23.98 ± 4.68, -0.59 ± 1.34 dB and 79.6 ± 8.3 um, respectively. IOP decreased significantly 4 month and 12 month after tafluprost administration (14.6 ± 2.4mmHg, P<0.001 and 14.6 ± 2.6mmHg, P<0.001, respectively). MBR increased significantly 4 month and 12 month after tafluprost administration (1.98 ± 7.80%, P=0.007 and 2.64 ± 10.43%, P=0.042, respectively).

Conclusions: Topical treatment with tafluprost decreases IOP and increases optic nerve blood flow with long-term stability in patients with PPG.

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