June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Lower baseline central retinal artery blood flow velocities predict structural progression in male patients with open-angle glaucoma
Author Affiliations & Notes
  • Rehan Hussain
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • Alon Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • Alice Chandra Verticchio Vercellin
    Eye Clinic, University of Pavia, Pavia, Italy
  • George Eckert
    Biostatistics, Indiana University School of Medicine, Indianapolis, IN
  • Claudia Thieme
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
    Ophthalmology, University Hospital, Berlin, Germany
  • Annahita Amireskandari
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • Noa Geffen
    Ophthalmology, Meir Medical Center, Kfar-Saba, Israel
  • Scott Wentz
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • Jenny Wang
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • Brent A Siesky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • Footnotes
    Commercial Relationships Rehan Hussain, None; Alon Harris, AdOM (I), Alcon (R), Biolight (C), Isama Therapeutics (C), Isama Therapeutics (R), Nano Retina (C), Ono (C), Science Based Health (C); Alice Chandra Verticchio Vercellin, None; George Eckert, None; Claudia Thieme, None; Annahita Amireskandari, None; Noa Geffen, None; Scott Wentz, None; Jenny Wang, None; Brent Siesky, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 2755. doi:
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      Rehan Hussain, Alon Harris, Alice Chandra Verticchio Vercellin, George Eckert, Claudia Thieme, Annahita Amireskandari, Noa Geffen, Scott Wentz, Jenny Wang, Brent A Siesky; Lower baseline central retinal artery blood flow velocities predict structural progression in male patients with open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):2755.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To examine the retrobulbar blood flow parameters and structural progression in males and females with open-angle glaucoma (OAG) over a 5-year period.

Methods: 111 OAG patients (Mean age 65 yr; 43 male, 68 female) were assessed for retrobulbar blood flow in the ophthalmic (OA) and central retinal (CRA) arteries as measured by color Doppler flowmetry at baseline and every 6 months for a 5 year period. 73 patients (Mean age 70 yr; 31 male, 42 female) were assessed at 5-year follow-up. Structural progression was monitored with optical coherence tomography, and Heidelberg retinal tomography and was defined as two consecutive visits with Retinal Nerve Fiber Layer thickness decrease ≥8% and/or horizontal or vertical cup/disk ratio increase ≥0.2 compared to baseline. Mixed-model ANCOVA was used to test for significant change from baseline to 5-year follow-up. Time to structural progression was analyzed using Cox proportional hazards models. Interactions were tested to determine if the effects of the factors on progression time differed by sex.

Results: In male and female patients from baseline over a 5-year period, CRA Peak Systolic Velocity (PSV) decreased with changes of -0.13 (-0.87, 0.60; p= 0.7233) in males and -0.96 (-1.51, -0.40; p=0.0008) in females. CRA End Diastolic Velocity (EDV) significantly decreased with changes of -0.98 (-1.45, -0.57; p<0.0001) in males and -0.66 (-1.00, -0.36; p<0.0001) in females. Lower baseline CRA PSV and EDV were associated with shorter time to structural progression in male (p=0.01) but not in female patients, leading to a significant difference between groups (p≤0.01).

Conclusions: In this group of patients, lower baseline CRA blood flow velocities were predictive of glaucomatous structural progression after 5 years in males but not in females. These data suggest that retrobulbar blood flow velocities may play a different role in the structural progression of the disease according to sex.

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