June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Lower ophthalmic artery blood flow velocities predict functional and structural glaucoma progression after 5 years
Author Affiliations & Notes
  • Alice Chandra Verticchio Vercellin
    Eye Clinic, University of Pavia, Pavia, Italy
  • Alon Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • Brent A Siesky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • George Eckert
    Biostatistics, Indiana University School of Medicine, Indianapolis, IN
  • Claudia Thieme
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
    Ophthalmology, University Hospital, Berlin, Germany
  • Leslie A Tobe
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • Yara Catoira-Boyle
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • Willy Gama
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • Nathaniel Kim
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • Footnotes
    Commercial Relationships Alice Chandra Verticchio Vercellin, None; Alon Harris, AdOM (I), Alcon (R), Biolight (C), Isama Therapeutics (C), Isama Therapeutics (R), Nano Retina (C), Ono (C), Science Based Health (C); Brent Siesky, None; George Eckert, None; Claudia Thieme, None; Leslie Tobe, None; Yara Catoira-Boyle, Alcon (R); Willy Gama, None; Nathaniel Kim, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 2756. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Alice Chandra Verticchio Vercellin, Alon Harris, Brent A Siesky, George Eckert, Claudia Thieme, Leslie A Tobe, Yara Catoira-Boyle, Willy Gama, Nathaniel Kim; Lower ophthalmic artery blood flow velocities predict functional and structural glaucoma progression after 5 years. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):2756.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: To examine the retrobulbar blood flow parameters and functional and structural progression in patients with open-angle glaucoma (OAG) over a 5-year period.

Methods: 112 OAG patients (Mean age 65 yr; 44 male) were assessed for retrobulbar blood flow in the ophthalmic (OA), central retinal (CRA), nasal (NPCA) and temporal (TPCA) posterior ciliary arteries as measured by color Doppler flowmetry at baseline and every 6 months for a 5-year period. 76 patients (Mean age 70 yr; 31 male) were assessed at 5-year follow-up. Functional disease progression was monitored with 24-2 Swedish Interactive Thresholding Algorithm visual field exam using the Humphrey visual field machine and defined as 2 consecutive visits with mean deviation decrease ≥2 and/or Advanced Glaucoma Intervention Study increase ≥2 compared to baseline. Structural progression was monitored with optical coherence tomography and Heidelberg retinal tomography and defined as two consecutive visits with Retinal Nerve Fiber Layer thickness decrease ≥8% and/or horizontal or vertical cup/disk ratio increase ≥0.2 compared to baseline. Mixed-model ANCOVA was used to test for significant change from baseline to 5-year follow-up. Times to functional and structural progression were analyzed using Cox proportional hazards models.

Results: OA Peak Systolic Velocity (PSV) was 23.0 (95% CI; 20.9, 25.4) at baseline, 21.8 (19.4, 24.4) at 5 years, change of -1.3 (-3.5, 0.7; p= 0.21), OA End Diastolic Velocity (EDV) significantly decreased from 5.6 (5.1, 6.2) at baseline to 3.9 (3.5, 4.4) at 5 years, change of -2.4 (-3.3, -1.6; p<0.0001). CRA PSV and EDV significantly decreased with changes of -0.6 (-1.1, -0.1; p=0.0126) and -0.8 (-1.1, -0.5; p<0.0001), respectively. NPCA and TPCA EDV significantly decreased with changes of -0.7 (-0.9, -0.4; p<0.0001) and -0.7 (-1.0, -0.5; p<0.0001), respectively, while neither NPCA nor TPCA PSV changed significantly. Resistivity indices (RI) in all retrobulbar vessels significantly increased over 5-years (p<0.0001). Lower OA PSV and OA EDV were associated with shorter time to functional and structural progression (p<0.05).

Conclusions: Retrobulbar blood flow velocities decreased and resistivity indices increased over 5 years. Lower OA blood flow velocities were predictive of glaucomatous functional and structural progression after 5 years.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×