June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Quantitative Analysis of Retinal Blood Flow in Normal and Glaucoma by Doppler Fourier-Domain Optical Coherence Tomography
Author Affiliations & Notes
  • Sowmya Srinivas
    Ophthalmology, Doheny Eye Institute, Los Angeles, CA
  • Muneeswar Gupta Nittala
    Ophthalmology, Doheny Eye Institute, Los Angeles, CA
  • Ou Tan
    Ophthalmolgy, Casey Eye Institute, Portland, OR
  • Rohit Varma
    Ophthalmology, University of Southern California, Los Angeles, CA
  • Brian A Francis
    Ophthalmology, Doheny Eye Institute, Los Angeles, CA
  • David S Greenfield
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Palm Beach Gardens, FL
  • Richard K Parrish
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Palm Beach Gardens, FL
  • Joel S Schuman
    Department of Ophthalmology, UPMC Eye Center,University of Pittsburgh, Pittsburgh, PA
  • Srinivas R Sadda
    Ophthalmology, Doheny Eye Institute, Los Angeles, CA
  • David Huang
    Ophthalmolgy, Casey Eye Institute, Portland, OR
  • Footnotes
    Commercial Relationships Sowmya Srinivas, None; Muneeswar Gupta Nittala, None; Ou Tan, Optovue, Inc (F), Optovue, Inc (P), Zeiss Meditec, Inc (P); Rohit Varma, AAerie Pharmaceutical (C), Allergan, Inc (C), AqueSys (C), Genentech (C), ISARNA (C), Merck & Co, Inc (C), National Eye Institute (F), Replenish, Inc. (C); Brian Francis, None; David Greenfield, None; Richard Parrish, None; Joel Schuman, Zeiss (P); Srinivas Sadda, Carl Zeiss Meditec (C), Carl Zeiss Meditec (F), Carl Zeiss Meditec (R), Optos (C), Optos (F), Optos (R); David Huang, Optovue, Inc (F), Optovue, Inc (P), Zeiss Meditec, Inc (P)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 2759. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Sowmya Srinivas, Muneeswar Gupta Nittala, Ou Tan, Rohit Varma, Brian A Francis, David S Greenfield, Richard K Parrish, Joel S Schuman, Srinivas R Sadda, David Huang, ; Quantitative Analysis of Retinal Blood Flow in Normal and Glaucoma by Doppler Fourier-Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):2759.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: To compare the total retinal blood flow (TRBF) in Normals, pre-perimetric glaucoma (PPG) and perimetric glaucoma (PG) eyes using Doppler Fourier-domain optical coherence tomography (FD-OCT) scans.

Methods: Fifty one eyes of 51 normal participants, sixty two eyes of 62 PPG participants and fifty one eyes of 51 PG patients from the 3 clinical centers of the Advanced Imaging Glaucoma Study were enrolled in this IRB-approved prospective study. Participants were scanned using Doppler FD-OCT imaging using a standardized, circumpapillary double circular scan protocol. The circular scans transected all major blood vessels entering/exiting the optic nerve head. The scans were graded using a semi-automated software at the Doheny Doppler OCT Reading Center. TRBF and other parameters were measured from branch retinal veins.

Results: The mean TRBF was 45.4 ± 9.8, 41.3 ± 11.8 and 38.1 ± 9.4µl/min in Normals, PPG and PG respectively. There was a significant difference (P= 0.003, ANOVA) in TRBF between the three groups. Compared to Normals, TRBF was significantly lower in PPG (P= 0.047, unpaired t-test) and PG (P <0.0001). Total venous area and average venous velocity were not significantly different between the groups.

Conclusions: As a group, a reduction in TRBF could be detected in suspected glaucoma subjects even in the pre-perimetric stage. Doppler OCT blood flow measurements may be of value in the evaluation of patients with glaucoma and warrant further investigation.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×