June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Retinal Microvascular Dysfunction occurs similarly in Alzheimer’s disease and Primary Open Angle Glaucoma patients
Author Affiliations & Notes
  • Stephanie Mroczkowska
    Ophthalmic Research Group, Aston University, Birmingham, United Kingdom
    Eye and Vision Research Group, Plymouth University, Plymouth, United Kingdom
  • Alexandra Benavente-Perez
    Ophthalmic Research Group, Aston University, Birmingham, United Kingdom
  • Sunni R Patel
    Ophthalmic Research Group, Aston University, Birmingham, United Kingdom
  • Anil Negi
    Medical Innovation Development and Research Unit, Heart of England NHS Foundation Trust, Birmingham, United Kingdom
  • Velota Sung
    Birmingham Midland Eye Centre, Sandwell and West Birmingham NHS Trust, Birmingham, United Kingdom
  • Peter Bentham
    Birmingham & Solihull Mental Health NHS Foundation Trust, Birmingham, United Kingdom
  • Doina Gherghel
    Ophthalmic Research Group, Aston University, Birmingham, United Kingdom
  • Footnotes
    Commercial Relationships Stephanie Mroczkowska, None; Alexandra Benavente-Perez, None; Sunni Patel, None; Anil Negi, None; Velota Sung, None; Peter Bentham, None; Doina Gherghel, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 2763. doi:
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      Stephanie Mroczkowska, Alexandra Benavente-Perez, Sunni R Patel, Anil Negi, Velota Sung, Peter Bentham, Doina Gherghel, ; Retinal Microvascular Dysfunction occurs similarly in Alzheimer’s disease and Primary Open Angle Glaucoma patients. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):2763.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: The exact nature of the relationship between Alzheimer’s disease (AD) and primary open angle glaucoma (POAG) is still the subject of debate. One factor attributed to the aetiology of both conditions is vascular dysfunction. This study aimed to investigate the similarities and differences in retinal microvascular function between mild AD patients, early stage POAG patients and healthy controls

Methods: Retinal vessel reactivity to flickering light was assessed in 10 AD, 19 POAG and 22 healthy age matched control patients by means of dynamic retinal vessel analysis (DVA, IMEDOS, GmbH, Jena, Germany) according to an established protocol. All patients additionally underwent BP measurements and blood analysis for glucose and lipid metabolism markers

Results: AD and POAG patients demonstrated comparable alterations in retinal artery reactivity, in the form of an increased arterial reaction time (RT) to flicker light on the final flicker cycle (p=0.014), which was not replicated in the healthy age and cardiovascular risk matched controls (p>0.05). Furthermore, the sequential changes in RT on progressing from flicker one to flicker three were found to differ between healthy controls and the two disease groups (p=0.001)

Conclusions: AD and POAG patients demonstrate comparable signs of vascular dysfunction in their retinal arteries at the early stages of their disease process. These comparable signs may reflect similarities in the pathophysiological processes that occur in the development of both conditions

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