June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Relationship of Central Choroidal Thickness with Age-Related Macular Degeneration Status
Author Affiliations & Notes
  • Glenn Yiu
    UC Davis, Sacramento, CA
    Duke University Medical Center, Durham, NC
  • Stephanie J. Chiu
    Duke University Medical Center, Durham, NC
  • Philip A Petrou
    National Eye Institute, Bethesda, MD
  • Sandra Stinnett
    Duke University Medical Center, Durham, NC
  • Neeru Sarin
    Duke University Medical Center, Durham, NC
  • Sina Farsiu
    Duke University Medical Center, Durham, NC
  • Emily Y Chew
    National Eye Institute, Bethesda, MD
  • Wai T Wong
    National Eye Institute, Bethesda, MD
  • Cynthia A Toth
    Duke University Medical Center, Durham, NC
  • Footnotes
    Commercial Relationships Glenn Yiu, None; Stephanie Chiu, None; Philip Petrou, None; Sandra Stinnett, None; Neeru Sarin, None; Sina Farsiu, None; Emily Chew, None; Wai Wong, None; Cynthia Toth, Alcon (F), Bioptigen (F), Genentech (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 2788. doi:
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      Glenn Yiu, Stephanie J. Chiu, Philip A Petrou, Sandra Stinnett, Neeru Sarin, Sina Farsiu, Emily Y Chew, Wai T Wong, Cynthia A Toth; Relationship of Central Choroidal Thickness with Age-Related Macular Degeneration Status. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):2788.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To compare choroidal thickness in patients with intermediate or advanced age-related macular degeneration (AMD) and control subjects using enhanced-depth imaging optical coherence tomography (EDI-OCT).

 
Methods
 

This is a retrospective cross-sectional study of 325 eyes from 164 subjects who underwent EDI-OCT for the Age-Related Eye Disease Study (AREDS) 2 Ancillary Spectral Domain OCT study. Choroidal thickness was measured by semi-automated segmentation of EDI-OCT images from 1.5mm nasal to 1.5mm temporal to the fovea. Multivariate linear regression was used to evaluate the association of subfoveal choroidal thickness or average choroidal thickness across the central 3mm segment with systemic and ocular variables. Choroidal thickness measurements were compared between eyes with no AMD (n = 154) (i.e. controls), intermediate AMD (n = 109), and advanced AMD (n = 62).

 
Results
 

Both subfoveal and average choroidal thicknesses were associated with age (P < 0.001) and refractive error (P < 0.001), but not other variables tested. Mean average choroidal thickness was significantly reduced in advanced AMD as compared with control eyes (P = 0.008), with no significant difference between advanced and intermediate AMD eyes (P = 0.152) or between intermediate AMD and control eyes (P = 0.098). Choroidal thinning was also noted from 1.5 mm nasal to 1.5 mm temporal to the fovea when comparing advanced AMD with control eyes (P < 0.05 at all 0.5mm interval locations). After adjustment for age and refractive error, however, there was no significant difference in subfoveal (p = 0.675) or average choroidal thickness (p = 0.746) across all three groups.

 
Conclusions
 

When adjusted for age and refractive error, central choroidal thickness may not be significantly influenced by AMD status based on AREDS categorization.  

 
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