June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Author Affiliations & Notes
  • Philipp Ken Roberts
    Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Bernhard Baumann
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
  • Christopher Schütze
    Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Stefan Sacu
    Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Matthias Bolz
    Ophthalmology and Optometry, General Hospital Linz, Linz, Austria
  • Michael Pircher
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
  • Christoph K Hitzenberger
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
  • Ursula Schmidt-Erfurth
    Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Footnotes
    Commercial Relationships Philipp Roberts, Canon Inc. (F); Bernhard Baumann, None; Christopher Schütze, None; Stefan Sacu, None; Matthias Bolz, None; Michael Pircher, Canon Inc. (F); Christoph Hitzenberger, Canon Inc. (F); Ursula Schmidt-Erfurth, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 2793. doi:
Abstract

Purpose: To investigate morphological retinal pigment epithelium (RPE) alterations in fellow eyes of patients diagnosed with unilateral neovascular age-related macular degeneration (nAMD) using polarization-sensitive optical coherence tomography (PS-OCT).

Methods: Thirty-one fellow eyes of 31 consecutive patients with unilateral nAMD were included in this prospective observational case series. PS-OCT was performed at baseline, month 1, months 3, 6 and 12 and every 12 months thereafter and whenever significant RPE-changes were diagnosed clinically. Conventional imaging systems including spectral-domain (SD-)OCT and fluorescein angiography (FA) were used for comparative imaging. Morphological features associated with the development of choroidal neovascularization (CNV) were analyzed.

Results: Mean follow-up was 29 months ±17 months. Thirteen (42%) of 31 eyes developed de novo CNV: 9 eyes type I CNV, 2 eyes type II CNV, 2 eyes a RAP lesion. Reticular pseudodrusen, readily identifiable by PS-OCT, were observed in 10 of the 13 eyes (77%) that progressed towards CNV and only 3 of 18 eyes (17%) that did not develop CNV. Monthly increases in drusen area and volume, measured by PS-OCT, were higher in the CNV group compared with the group not developing CNV.

Conclusions: Progression of early AMD to CNV is preceded by qualitative and quantitative RPE alterations. An increase in drusen area/volume may be an indicator for progression to nAMD. PS-OCT may represent a useful tool for individual risk stratification and early CNV detection.

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