June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Source-resolved EEG analysis of human saccade-event related potentials
Author Affiliations & Notes
  • Makoto Miyakoshi
    SCCN, Inc, University of California San Diego, La Jolla, CA
  • Scott Makeig
    SCCN, Inc, University of California San Diego, La Jolla, CA
  • Carolina Gracitelli
    Visual Performance Laboratory, Department of Ophthalmology,, University of California San Diego, La Jolla, CA
    Ophthalmology, Federal University of São Paulo, São Paulo, Brazil
  • Ricardo Yuji Abe
    Ophthalmology, University of Campinas, Campinas, Brazil
    Visual Performance Laboratory, Department of Ophthalmology,, University of California San Diego, La Jolla, CA
  • Alberto Diniz-Filho
    Visual Performance Laboratory, Department of Ophthalmology,, University of California San Diego, La Jolla, CA
    Department of Ophthalmology and Otorhinolaryngology, Federal University of Minas Gerais, Belo Horizonte, Brazil
  • Saif Baig
    Visual Performance Laboratory, Department of Ophthalmology,, University of California San Diego, La Jolla, CA
  • Felipe A Medeiros
    Visual Performance Laboratory, Department of Ophthalmology,, University of California San Diego, La Jolla, CA
  • Footnotes
    Commercial Relationships Makoto Miyakoshi, None; Scott Makeig, None; Carolina Gracitelli, None; Ricardo Abe, None; Alberto Diniz-Filho, None; Saif Baig, None; Felipe Medeiros, Alcon Laboratories Inc (F), Alcon Laboratories Inc (R), Allergan Inc (C), Allergan Inc (F), Allergan Inc (R), Bausch & Lomb (F), Carl Zeiss Meditec Inc (C), Carl Zeiss Meditec Inc (F), Carl Zeiss Meditec Inc (R), Heidelberg Engineering Inc (F), Merck Inc (F), National Eye Institute (F), Novartis (C), Reichert Inc (F), Reichert Inc (R), Sensimed (F), Topcon Inc (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 2919. doi:
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    • Get Citation

      Makoto Miyakoshi, Scott Makeig, Carolina Gracitelli, Ricardo Yuji Abe, Alberto Diniz-Filho, Saif Baig, Felipe A Medeiros; Source-resolved EEG analysis of human saccade-event related potentials. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):2919.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

We developed an active visual search task in which participants saccade freely across an evolving display of Gabor patches. Here we report the results from the EEG analyses of saccade-related brain/muscle potentials using independent component analysis (ICA) and independent component (IC) clustering.

 
Methods
 

Participants were 16 healthy young adults (8 female, mean 20.8 years, SD 2.8, range 18-26). Five Gabor patches were always present on a gray background (20-inch LCD monitor at 60 cm ). A sequence of 1200 patches were pseudo-randomly selected from four patch sizes and five orientations (SOA 2 sec, duration 5 sec). The task was to detect infrequent (15%) instances in which the size and orientation of the newest patch matched those of another patch that was still visible, prompting a button press. Eye-tracking data were obtained from the left eye while 205-channel, 512-Hz scalp EEG data were recorded. We studied event-related potentials (ERPs) time-locked to saccade events for the time courses of 650 localizable ICs assigned to 16 clusters.

 
Results
 

Mean response accuracy was 92% (SD: 5%) with mean false positive rate 6% (SD: 4%). Mean reaction time was 1579 ms (SD: 235 ms). After excluding 3 frontal EOG clusters comprising 240 ICs, the major (90 ms) lambda response peak in the fixation-onset locked ERPs was dominated by 3 occipital IC clusters (100 ICs, 92% of the peak scalp map accounted for) (Figure 1). ERPs time locked to saccade onsets contained a pre-saccadic spike peaking at -12 ms. Three far frontal clusters dominated this spike (260 ICs, 95% variance accounted) (Figure 2 left). However, after removing all 5 EOG and far frontal clusters (314 ICs) and 1 temporal scalp muscle (EMG) cluster (26 ICs), 4 posterior clusters (114 ICs) contributed 82% of the remaining (positive-going) pre-saccadic spike (Figure 2 right).

 
Conclusions
 

ICA clustering analysis revealed multiple sources of the lambda response and pre-saccadic spikes. Posterior cortical contributions to the pre-saccadic spike might index corollary suppression of visual cortex during saccades. We plan to use this task to investigate functional vision in glaucoma patients.  

 
Figure 1. Lambda response. Occipital IC source clusters of the lambda response following fixation onsets.
 
Figure 1. Lambda response. Occipital IC source clusters of the lambda response following fixation onsets.
 
 
Figure 2. Pre-saccadic spike. Left, EOG/far frontal source contributions are dominant. Right, posterior brain source contributions remaining after removing EOG and EMG ICs.
 
Figure 2. Pre-saccadic spike. Left, EOG/far frontal source contributions are dominant. Right, posterior brain source contributions remaining after removing EOG and EMG ICs.

 
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