Purchase this article with an account.
Jose-Carlos Pastor, Isabel Alexandre, Mar Justel, Prudencio Martinez, Raul Ortiz de Lejarazu; Ophthalmia Neonatorum (ON) in Angola: Results of the first attempt to develop a prophylaxis program. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3031.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To study the efficacy of povidone-iodine (P-I) prophylaxis for ophthalmia neonatorum (ON) in Angola and to document the maternal prevalence and mother-to-child transmission rates of three important infectious agents
After ethical approval by Agostinho Neto University committee the study was conducted at General Augusto N'Gangula Specialized Hospital and Health Center of Samba, both in Luanda, Angola from 7-Dec-2011 to 22-Nov-2012. Inclusion criteria consisted of healthy children weighing at least 2.3 kg and a gestation period of at least 37 weeks. Endocervical samples from mothers (n=312) and newborn conjunctival smears (n=245) were analyzed by multiplex polymerase chain reaction (PCR) for Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Mycoplasma genitalium (MG). After ophthalmological examination, the newborns were randomized into a non-interventional group (no local treatment) and an interventional group that received a drop of P-I 2.5% bilaterally after conjunctival smear collection. Mothers were trained to identify signs of ON and attend a follow-up visit 7-10 days after discharge
Forty-four (17.9%) newborns had pathologic ocular findings, and 11 (4.5%) had clinical signs consistent with ON at the time of delivery. Maternal PCR was positive for MG (n=19), CT (n=8), and NG (n=2) (one mother had two microorganisms: CT and MG).. Eight newborns were positive for CT (n=4), MG (n=3), and NG (n=1). Mother-to-child transmission rates were 50% for CT and NG and 10.5% for MG. Ten of the positive mothers had risk factors for M-C-T. No relationship could be established between external signs of acute conjunctivitis and maternal genito-urinary infections. Only 16 of the newborns were returned for a follow-up visit
The lack of maternal compliance prevented the successful testing of prophylactic P-I efficacy in ON prevention. Nevertheless, we documented the prevalence and mother-to-child rates for CT, NG, and MG. These results emphasize the need to educate the Angolan public on the origins of ON and to develop an effective prophylaxis program
This PDF is available to Subscribers Only