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Rafael S Grajewski, Anna C Boelke, Sina Meyer, Bernd Kirchhof, Claus Cursiefen, Ludwig M Heindl; Spectral-domain optical coherence tomography findings in 506 consecutive patients with uveitis. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3125.
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© ARVO (1962-2015); The Authors (2016-present)
To analyze the macular structure in a large series of consecutive patients with different types of uveitis using spectral-domain optical coherence tomography (SD-OCT).
1012 eyes of 506 consecutive patients with anterior, intermediate, posterior and panuveitis underwent standardized macular examination using SD-OCT (Heidelberg Engineering, Germany). Central retinal thickness (CRT), macular volume (MV), and presence of cystoid macular edema (CME), diffuse macular edema (DME), serous retinal detachment (SRM), epiretinal membrane with (ERM+) and without (ERM-) retinal surface wrinkling were determined.
In dependence of the anatomic location of inflammation, mean CRT was 327.72 mm (+ 106.29) in anterior uveitis, 356.80 mm (+ 123.40) in intermediate uveitis, 310.15 mm (+ 122.47) in posterior uveitis and 363.08 mm (+ 143.10) in panuveitis. The average MV was 3.35 mm3 (+ 0.51) in anterior uveitis, 3.55 mm3 (+ 0.68) in intermediate uveitis, 3.25 mm3 (+ 0.70) in posterior uveitis and 3.54 mm3 (+ 0.65) in panuveitis. Statistically, the differences between the anatomic location of inflammation regarding CRT and MV were significant (p<0.001, respectively). CME was seen in 20% of all uveitic eyes, DME in 10%, SRD in 6%, ERM+ in 14% and ERM- in 12%. In dependence of the location, CME was detected in 18% in anterior uveitis, 28% in intermediate uveitis, 14% in posterior uveitis, and 27% in panuveitis.
Standardized spectral-domain optical coherence tomography of the macula is recommended for all uveitis patients. CRT, MV and the incidence of CME were different regarding the anatomic location of inflammation, and were highest in intermediate and panuveitis.
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