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Miin Roh, Heeyoon Cho, Cagla Yasa, Laura Nicholson, Eduardo Uchiyama, Lucy H Young, Marlene Durand, Ann-Marie Lobo, George Papaliodis, Lucia Sobrin; Toxoplasmosis Antibody Titers as a Supportive Tool in the Diagnosis of Ocular Toxoplasmosis. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3133.
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© ARVO (1962-2015); The Authors (2016-present)
Ocular toxoplasmosis is the most frequent cause of infectious posterior uveitis. Although the classic teaching is that the anti-toxoplasmosis antibody titer is not particularly informative in the diagnosis, there are very few studies that have examined the role of serologic testing. The purpose of this study is to determine whether a correlation between toxoplasmosis antibody titers and ocular toxoplasmosis presence and activity exists.
We retrospectively reviewed charts of patients who had positive serologic testing for Toxoplasmosis gondii IgG antibodies using an enzyme linked immunosorbent assay. A cross-sectional study was performed using analysis of variance to compare IgG levels among patients who had active toxoplasmosis chorioretinitis (TC), inactive TC , and non-toxoplasmosis uveitis patients. A longitudinal investigation to compare toxoplasmosis IgG titers in subset of patients who had serial serologic testing at the time of active and inactive TC was performed using the paired t test. All analyses were performed in StataIC 12 (Stata, College Station, TX).
81 patients with active TC, 31 patients with inactive TC, and 54 patients nontoxoplasmosis uveitis were identified. In the cross-sectional analysis, mean toxoplasmosis IgG titers were not significantly different between active TC (164.1 ± 97.1 IU/ml) vs. inactive TC (145.3 ± 108.9 IU/ml) ( P=0.10). There was, however, a significantly lower level (90.4 ± 86.6 IU/ml) in non-toxoplasmosis uveitis patients (P< 0.001). In the longitudinal analysis of the subset of 22 patients with ocular toxoplasmosis, there was no significant difference in the mean level of toxoplasmosis IgG: 160.1 IU/ml during active disease vs. 191.3 IU/ml once the disease was inactive (P=0.19).
Toxoplasmosis IgG titers were higher in patients with ocular toxoplasmosis, whether the disease was active or inactive, as compared to non-toxoplasmosis uveitis patients. Both cross-sectional and longitudinal data failed to show any difference in toxoplasmosis IgG titers in active vs. inactive ocular toxoplasmosis. Future studies are needed to confirm whether the degree of toxoplasmosis IgG titer elevation might be useful in distinguishing whether atypical presentations of chorioretinitis are due to toxoplasmosis.
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