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Nicole K Scripsema, Chavakij Bhoomibunchoo, Paul Whitten, Robert Masini, Richard B Rosen; Fluorescein Angiography and Retinal Vessel Oxygen Saturation in Patients with Proliferative Diabetic Retinopathy.. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3309.
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© ARVO (1962-2015); The Authors (2016-present)
To determine oxygen saturation differences between areas of active versus inactive Proliferative Diabetic Retinopathy (PDR) using the Oxymap Retinal Oximeter.
Following a previous study which demonstrated increased oxygen saturation in retinal vessels proportional to the severity of Diabetic Retinopathy1, a retrospective review of diabetic patients with PDR was performed. Patients imaged using both fluorescein angiography (FA, Topcon, USA) and Oxymap T1 (Reykjavik, Iceland) were included. Relative oxygen saturation of retinal vessels was analyzed with the Oxymap. Retinal vessels associated with areas of neovascularization on FA were compared to areas of inactive disease. Paired t-tests were used to compare oxygen saturations.
48 eyes of 29 patients were included. 10 eyes were excluded due to inadequate image quality. Mean age was 53.83±9.11 yrs. 62% were female, 38% male. 44% were Hispanic, 26% African Americn, 11% Asian, 10% Caucasion, and 9% Other. Mean duration of diabetes (DM) was 19.85±8.83 yrs. Mean hemoglobin A1c was 9.47±3.81%. A majority of patients were initially diagnosed with Type II DM (82.8%), now requiring both insulin and oral hypoglycemics for glycemic control (84.6%). Mean relative arterial oxygen saturation was higher in vessels associated with neovascularization when compared to vessels in regions with no active disease (107.93±13.85%, 104.87±14.25%, p=0.14). Mean relative venous oxygen saturation was significantly lower in vessels associated with neovascularization when compared to vessels in regions with no active disease (66.05±11.87%, 69.57±9.19%, p=0.02).
These results suggest oxygen saturation in retinal vessels associated with neovascularization varies from areas of inactive disease. Our findings of higher arterial oxygen saturation are consistent with a previous study that reported increased oxygen saturation proportional to the severity of retinopathy. The lower venous oxygen saturation in vessels associated with neovascularization could be related increased leakage in areas of angiogenesis. Initial data suggests the Oxymap could serve as a clinically useful non-invasive imaging method for monitoring disease progression. Further studies are needed to unravel the correlation between Oxymap results and FA findings.<br /> <br /> Reference:<br /> 1. Jørgensen CM et al. Acta Ophthalmol. 2014 Feb;92(1):34-9.
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