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Karel Van Keer, Cathy De Deyne, Cornelia Genbrugge, Luis Pinto, Evelien Vandewalle, Ingeborg Stalmans; Retinal oximetry as a novel parameter in the non-invasive assessment of cerebral oxygenation. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3312.
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To investigate the relation between retinal and cerebral oximetry, as measured by non-invasive spectroscopy and to establish the relative partition of arterial and venous retinal oxygen saturation to the measured cerebral oxygen saturation.
In this observational, cross-sectional study we performed peripheral, retinal and cerebral oxygen saturation measurements in healthy volunteers during steady state conditions. Peripheral oxygen saturation was measured on the left index finger by pulse oximetry (Ohmeda TruSat Pulse Oximeter, GE Healthcare, Finland). Arterial and venous retinal oxygen saturation and vessel diameter were measured in the left eye using a noninvasive spectrophotometric retinal oximeter (Oxymap T1, Oxymap ehf., Reykjavik, Iceland). Cerebral oxygen saturation was measured over the left cerebral cortex using cerebral near-infrared spectroscopy (NIRS) (FORE-SIGHT technology, CAS Medical Systems, Branford, CT). Correlations between the parameters were assessed using Pearson correlation coefficients. The relative arterial and venous partition was determined.
21 young healthy individuals aged 26.4±2.2 years were analyzed. Cerebral oxygen saturation values showed a significant positive correlation with both arterial and venous retinal vessel oxygen saturation values (r = 0.442, P=0.045 and r = 0.434 P=0.049 respectively) and a significant negative correlation with retinal venous diameter (Pearson correlation coefficient = -0.513, P=0.017). The relative partition of arterial and venous retinal oxygen saturation to the cerebral oxygen saturation value was 31.5% and 68.5% respectively.<br /> Peripheral oxygen saturation was correlated neither with cerebral nor with retinal oxygen saturation.
This is the first study to show a correlation between retinal and cerebral oximetry, as measured by non-invasive spectroscopy.<br /> The observed relative partition of arterial and venous retinal oxygen saturation is very close to the established calibration of FORE-SIGHT NIRS technology to a weighted average of 30% arterial and 70% venous contribution. Therefore, our first findings support a promising role for retinal oximetry as a non-invasive reliable tool in evaluating cerebral oxygenation in health and disease.
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