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Elaine Downie, Julian Tokarev, Afshin Divani, Dara D Koozekanani; Comparison of two free retinal vascular measurement software packages: IVAN and VAMPIRE. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3320.
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© ARVO (1962-2015); The Authors (2016-present)
Retinal image analysis can be used to quantify retinal vascular changes due to hypertensive retinopathy, changes shown to be predictive of stroke risk. A number of software packages are available for this, and each utilizes different techniques for detection and measurement of retinal vascular features. Here, we compared the performance of a well known package, IVAN, with a newly available tool, VAMPIRE.
50 degree color fundus images obtained with a Topcon TRC 50DX camera (Topcon Medical Systems, Oakland, NJ) were graded using IVAN (Interactive Vessel ANalyzer), v1.3 (courtesy of Dr. Nicola Ferrier of the UW Madison School of Engineering and the Dept. of Ophthalmology and Visual Sciences) and VAMPIRE (Vascular Assessment and Measurement Platform for Images of the Retina, available at vampire.computing.dundee.ac.uk). Both are available free of charge. Both were used to calculate central retinal artery equivalents (CRAE), central retinal vein equivalents (CRVE), and arteriolar:venular ratio (AVR) for each eye.
21 patients, 42 eyes, were analyzed. CRAE, CRVE, and AVR values were obtained for 41 eyes, one eye was ungradeable. The values were plotted and a correlation coefficient between the IVAN and VAMPIRE values was calculated and tested for significance using the Pearson Product-Moment Significance Test. For CRVE, the R2=0.7032, the Pearson correlation coefficient (R)=0.839, p<0.001. For CRAE, the R2=0.2604, the Pearson correlation coefficient (R)=0.510, p=0.001. For AVR, the R2=0.5747, the Pearson correlation coefficient (R)=0.758, p<0.001.
The CRAE, CRVE, and AVR values measured with the newer VAMPIRE software package corresponded with those obtained using IVAN. While the two packages use different methods and have different degrees of automaticity, this suggests both can be valuable tools in the investigation of hypertensive retinopathy and other retinal vascular conditions for which CRAE, CRVE, and AVR are relevant.
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