June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Comparison of two free retinal vascular measurement software packages: IVAN and VAMPIRE
Author Affiliations & Notes
  • Elaine Downie
    University of Minnesota Medical School, Minneapolis, MN
  • Julian Tokarev
    University of Minnesota Medical School, Minneapolis, MN
  • Afshin Divani
    Department of Neurology, University of Minnesota, Minneapolis, MN
  • Dara D Koozekanani
    Department of Ophthalmology, University of Minnesota, Minneapolis, MN
  • Footnotes
    Commercial Relationships Elaine Downie, None; Julian Tokarev, None; Afshin Divani, None; Dara Koozekanani, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3320. doi:
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      Elaine Downie, Julian Tokarev, Afshin Divani, Dara D Koozekanani; Comparison of two free retinal vascular measurement software packages: IVAN and VAMPIRE. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3320.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

Retinal image analysis can be used to quantify retinal vascular changes due to hypertensive retinopathy, changes shown to be predictive of stroke risk. A number of software packages are available for this, and each utilizes different techniques for detection and measurement of retinal vascular features. Here, we compared the performance of a well known package, IVAN, with a newly available tool, VAMPIRE.

 
Methods
 

50 degree color fundus images obtained with a Topcon TRC 50DX camera (Topcon Medical Systems, Oakland, NJ) were graded using IVAN (Interactive Vessel ANalyzer), v1.3 (courtesy of Dr. Nicola Ferrier of the UW Madison School of Engineering and the Dept. of Ophthalmology and Visual Sciences) and VAMPIRE (Vascular Assessment and Measurement Platform for Images of the Retina, available at vampire.computing.dundee.ac.uk). Both are available free of charge. Both were used to calculate central retinal artery equivalents (CRAE), central retinal vein equivalents (CRVE), and arteriolar:venular ratio (AVR) for each eye.

 
Results
 

21 patients, 42 eyes, were analyzed. CRAE, CRVE, and AVR values were obtained for 41 eyes, one eye was ungradeable. The values were plotted and a correlation coefficient between the IVAN and VAMPIRE values was calculated and tested for significance using the Pearson Product-Moment Significance Test. For CRVE, the R2=0.7032, the Pearson correlation coefficient (R)=0.839, p<0.001. For CRAE, the R2=0.2604, the Pearson correlation coefficient (R)=0.510, p=0.001. For AVR, the R2=0.5747, the Pearson correlation coefficient (R)=0.758, p<0.001.

 
Conclusions
 

The CRAE, CRVE, and AVR values measured with the newer VAMPIRE software package corresponded with those obtained using IVAN. While the two packages use different methods and have different degrees of automaticity, this suggests both can be valuable tools in the investigation of hypertensive retinopathy and other retinal vascular conditions for which CRAE, CRVE, and AVR are relevant.  

 
Figure 1. IVAN segments vessels within a ring between 0.5 and 1 disc diameters from the disc center. The grader verifies correct vessel identification and revises the segmentations. CRAE, CRVE, and AVR are calculated using the Parr-Hubbard-Knudtson equation.
 
Figure 1. IVAN segments vessels within a ring between 0.5 and 1 disc diameters from the disc center. The grader verifies correct vessel identification and revises the segmentations. CRAE, CRVE, and AVR are calculated using the Parr-Hubbard-Knudtson equation.
 
 
Figure. 2A VAMPIRE displays concentric rings and allows the user to designate points for vascular measurement.<br /> Figure. 2B Vascular measurement is made manually with a measuring tool.
 
Figure. 2A VAMPIRE displays concentric rings and allows the user to designate points for vascular measurement.<br /> Figure. 2B Vascular measurement is made manually with a measuring tool.

 
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