June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Methodology for visualization of reduced choriocapillaris density using optical coherence tomography angiography
Author Affiliations & Notes
  • Simon S Gao
    Ophthalmology, Oregon Health & Science University, Portland, OR
  • Yali Jia
    Ophthalmology, Oregon Health & Science University, Portland, OR
  • Nieraj Jain
    Ophthalmology, Oregon Health & Science University, Portland, OR
  • Mark E Pennesi
    Ophthalmology, Oregon Health & Science University, Portland, OR
  • David Huang
    Ophthalmology, Oregon Health & Science University, Portland, OR
  • Footnotes
    Commercial Relationships Simon Gao, None; Yali Jia, Optovue, Inc. (F), Optovue, Inc. (P); Nieraj Jain, None; Mark Pennesi, Sucampo Pharmaceuticals (C); David Huang, Carl Zeiss Meditec, Inc. (P), Optovue, Inc. (F), Optovue, Inc. (I), Optovue, Inc. (P)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3327. doi:
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    • Get Citation

      Simon S Gao, Yali Jia, Nieraj Jain, Mark E Pennesi, David Huang; Methodology for visualization of reduced choriocapillaris density using optical coherence tomography angiography. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3327.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To develop a method of visualizing reduced choriocapillaris density using optical coherence tomography (OCT) angiography.

 
Methods
 

Macular scans of a participant with a clinical diagnosis of choroideremia were taken using a spectral OCT system (RTVue-XR) and compared with normal participants. The split-spectrum amplitude-decorrelation angiography algorithm was used to detect flow. The inner retinal layer from the internal limiting membrane to 90 µm below showed the retinal circulation. The choriocapillaris layer was defined to be 10 µm below Bruch’s membrane to 20 µm below. Flow projections from retinal vessels were treated as null in the choriocapillaris layer. The choriocapillaris angiogram was then split into 8x8 superpixels, and the vessel density was calculated for each superpixel. This vessel density map was then smoothed using linear interpolation.

 
Results
 

In the choroideremia case, en face OCT angiogram of the retinal circulation appeared normal (Fig. 1A). The en face structural OCT of the retinal pigment epithelium (RPE) showed hyporeflective regions indicating RPE loss (Fig. 1B). The choriocapillaris angiogram and vessel density map showed distinct areas of reduced flow (Fig. 1C-E). Overlay (Fig. 1F) showed patches of reduced choriocapillaris vessel density within regions of RPE loss.

 
Conclusions
 

We have developed a method to visualize reduced choriocapillaris density. This method may be useful in the assessment of diseases such as choroideremia and age-related macular degeneration.  

 
Figure 1. (A) En face OCT angiogram of the retinal circulation in a patient with choroideremia. (B) En face OCT structural image of the retinal pigment epithelium. (C) OCT angiogram of the choriocapillaris. (D) Vessel density map of the choriocapillaris. (E) Smoothed vessel density map. Scale bar shows vessel density from 0% (blue) to 100% (red). (F) Areas where the vessel density was less than 50% (pink-purple) overlaid on (B).
 
Figure 1. (A) En face OCT angiogram of the retinal circulation in a patient with choroideremia. (B) En face OCT structural image of the retinal pigment epithelium. (C) OCT angiogram of the choriocapillaris. (D) Vessel density map of the choriocapillaris. (E) Smoothed vessel density map. Scale bar shows vessel density from 0% (blue) to 100% (red). (F) Areas where the vessel density was less than 50% (pink-purple) overlaid on (B).

 
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