Purchase this article with an account.
Anthony Joseph, Talisa E de Carlo, Mehreen Adhi, Eric Moult, Nadia Waheed, Caroline Baumal, Woo Jhon Choi, James G Fujimoto, Jay S Duker, Andre Witkin; Sensitivity and Specificity of Ultra-High Speed Optical Coherence Tomography Angiography in Detection of Choroidal Neovascularization in Neovascular Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3330.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To estimate the sensitivity and specificity for the detection of choroidal neovascularization (CNV) using ultrahigh speed swept source optical coherence tomography angiography (SS-OCTA) in patients with neovascular age-related macular degeneration (AMD).
In this retrospective observational cross-sectional study, patients with a clinical diagnosis of neovascular AMD were evaluated at New England Eye Center between January 2014 and November 2014. 25 patients who received ultrahigh speed SS-OCTA (Massachusetts Institute of Technology, Cambridge MA) and 50-degree fluorescein angiography (FA) on the same day were evaluated. The SS-OCTA software co-registers the SS-OCTA en-face angiograms with SS-OCTA correlating b-scans allowing for visualization of structure and blood flow in tandem. FA, SS-OCTA angiograms, and SS-OCTA correlating b-scans were independently reviewed by two masked Boston Image Reading Center (BIRC) trained readers to identify CNV. Sensitivity and specificity of CNV detection using SS-OCTA were calculated using FA as the ground truth in three different ways: (1) SS-OCTA angiograms alone (2) SS-OCTA correlating b-scans alone (3) SS-OCTA angiograms and correlating b-scans.
Sensitivity of CNV detection was moderate when using either SS-OCTA angiograms or SS-OCTA correlating b-scans alone. However, sensitivity improved when using the SS-OCTA images in tandem. Specificity was high in all three groups.
SS-OCTA is able to non-invasively visualize CNV which may provide a method for identifying and guiding treatment of CNV. The sensitivity and specificity of CNV detection on ultra-high SS-OCTA compared with FA appears high. Future studies with larger sample sizes are needed to better elaborate on the sensitivity and specificity of CNV detection and illustrate clinical utility.
This PDF is available to Subscribers Only