June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
OCT Angiography (OCTA) of Macular Neovascularization (MNV)
Author Affiliations & Notes
  • Emeline Radhika Ramenaden
    Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • John Edward Legarreta
    Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • Andrew Dominic Legarreta
    Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • Douglas Matsunaga
    USC Eye Center, Keck School of Medicine, University of Southern California, Los Angeles, CA
  • Amir H Kashani
    USC Eye Center, Keck School of Medicine, University of Southern California, Los Angeles, CA
  • Giovanni Gregori
    Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • Qinqin Zhang
    Bioengineering, University of Washington, Seattle, WA
  • Ruikang K Wang
    Bioengineering, University of Washington, Seattle, WA
  • Carmen A Puliafito
    USC Eye Center, Keck School of Medicine, University of Southern California, Los Angeles, CA
  • Philip J Rosenfeld
    Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • Footnotes
    Commercial Relationships Emeline Ramenaden, Carl Zeiss Meditec, Inc (F); John Legarreta, Carl Zeiss Meditec, Inc (F); Andrew Legarreta, Carl Zeiss Meditec, Inc (F); Douglas Matsunaga, Carl Zeiss Meditec, Inc (F); Amir Kashani, Carl Zeiss Meditec, Inc (F); Giovanni Gregori, Carl Zeiss Meditec, Inc (F), Carl Zeiss Meditec, Inc (P); Qinqin Zhang, Carl Zeiss Meditec, Inc (F); Ruikang Wang, Carl Zeiss Meditec, Inc (F); Carmen Puliafito, Carl Zeiss Meditec, Inc (F); Philip Rosenfeld, Carl Zeiss Meditec, Inc (F)
  • Footnotes
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Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3334. doi:
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    • Get Citation

      Emeline Radhika Ramenaden, John Edward Legarreta, Andrew Dominic Legarreta, Douglas Matsunaga, Amir H Kashani, Giovanni Gregori, Qinqin Zhang, Ruikang K Wang, Carmen A Puliafito, Philip J Rosenfeld; OCT Angiography (OCTA) of Macular Neovascularization (MNV). Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):3334.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To evaluate the microvasculature of the central macula in eyes with macular neovascularization (MNV) using swept-source (SS) and spectral-domain (SD) optical coherence tomography (OCT) angiography.

 
Methods
 

Subjects were enrolled in a prospective, observational study and evaluated using a high-speed 1050 nm SS-OCT prototype system (100,000 kHz) and a 840 nm SD-OCT prototype system (68,000 kHz). SS-OCT angiography was performed using a 3X3mm raster scan pattern centered on the fovea. In the transverse scanning direction, a single B-scan was comprised of 300 A-scans. Four consecutive B-scans were performed at each fixed position before proceeding to the next transverse position on the retina. A total of 300 B-scan positions located 10 μm apart over a 3 mm distance were sampled. SD-OCT angiography was performed using a 3X3mm and 6X6mm raster scan pattern. In the 3X3 raster scan, four consecutive B-scans, each comprised of 245 A-scans, was performed in the transverse scanning direction. In the 6X6 raster scan pattern, the transverse scanning direction was comprised of two consecutive B-scans, each of 350 A-scans. A total of 245 B-scan positions were located 12.4 μm apart over the 3 mm distance, and a total of 350 B-scan positions were located 17.1 μm apart over the 6 mm distance. Algorithms segmented the retina into three layers; an inner retinal layer, a middle retinal layer, and an outer retinal layer. The choriocapillaris and choroidal vasculature were further segmented. The vascular distribution in each layer was depicted as an en face image. En face OCT angiographic images were compared to early and late phase fluorescein angiography (FA) images.

 
Results
 

Imaging was performed using the SS-OCT and SD-OCT instruments. OCT angiography of MNV showed well-defined microvascular networks. Furthermore, imaging before and after treatment with aflibercept demonstrated a decrease in size of the microvascular network after therapy. The decreased size of the neovascular network exposed marked flow impairment in the underlying choriocapillaris. Images obtained with both the SS-OCT and SD-OCT instruments are being compared in this ongoing study.

 
Conclusions
 

OCTA, which can be performed with both SS-OCT and SD-OCT instruments, provides rapid, non-invasive, high-resolution, depth-resolved, images comparable to or even better than conventional fluorescein angiography in eyes with macular neovascularization.

 
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